Affinity DataEC50: 0.510nMAssay Description:Activation of recombinant PKM2 (unknown origin) Phe26, Tyr390, Glu397, Asp354, Leu353 residuesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Activation of recombinant PKM2 (unknown origin) Glu397, Lys3I I, Asp354, Leu353, Tyr390, His391 residuesMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Activation of recombinant human PKM2 expressed in Escherichia coli BL21 at 4 uM incubated for 50 mins measured over 40 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 7.10nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Activation of PKM2 in human Huh7 cells assessed as production of pyruvate and ATP by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 23nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 37nMAssay Description:Activation of PKM2 (unknown origin) Lys311, Asp354, Met30, Phe26 residuesMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Activation of PKM2 (unknown origin) Phe26, Tyr390, Glu397, Leu353 residuesMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: 38nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Activation of PKM2 (unknown origin) Asp354, Phe26, Lys311 residuesMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Activation of human recombinant full length His-tagged PKM2 (Asp354, Lys311, Glu397, Gly315 residues)More data for this Ligand-Target Pair
Affinity DataEC50: 56nMAssay Description:Activation of PKM2 (unknown origin) Leu353, Tyr390, Phe26, Glu397, Lys311, Asp354 residuesMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:Activation of PKM2 in human Huh7 cells assessed as production of pyruvate and ATP by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 73nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 90nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 90nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 90nMAssay Description:Activation of PKM2 (unknown origin) Glu397, Phe26, Tyr390, Leu353 residuesMore data for this Ligand-Target Pair
Affinity DataEC50: 92nMAssay Description:Activation of recombinant human PKM2 expressed in Escherichia coli BL21 at 4 uM incubated for 50 mins measured over 40 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 92nMAssay Description:Activation of human recombinant full length His-tagged PKM2 (Asp354, Lys311, Glu397, Gly315 residues)More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 170nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 210nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 210nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 220nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 228nMAssay Description:Activation of PKM2 (unknown origin) Glu397, Phe26, Leu353, Gly355 residuesMore data for this Ligand-Target Pair
Affinity DataEC50: 230nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 240nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 410nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 440nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 440nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 480nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 510nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 540nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 560nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 570nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
Affinity DataEC50: 600nMAssay Description:Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assayMore data for this Ligand-Target Pair
