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PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50280813(5-[(1S,2S)-1-Hydroxy-2-(4-phenyl-piperidin-1-yl)-p...)

IC50: 40nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)

IC50: 55nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair

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PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50091649(6-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-1-meth...)

IC50: 98nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2B NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50078498(4-[3-(4-Benzyl-piperidin-1-yl)-prop-1-ynyl]-phenol...)

IC50: 100nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50280812(5-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-p...)

IC50: 111nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50078480(4-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-phenol ...)

IC50: 170nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50038162(5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione | CH...)

IC50: 170nMAssay Description:Compound was evaluated for in vitro inhibition of [3H]L-689,560 at NMDA receptor.More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440067(CHEMBL2426072 | CHEMBL2426073)

IC50: 200nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440060(CHEMBL2426081)

IC50: 220nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50280811(5-[(1R,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-p...)

IC50: 231nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50007674((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)

IC50: 263nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50038162(5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione | CH...)

IC50: 400nMAssay Description:Compound was evaluated for in vitro inhibition of cortical slice release at NMDA receptor.More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440084(CHEMBL2426093)

IC50: 560nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50280810(5-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-1-hydrox...)

IC50: 600nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440065(CHEMBL2426075)

IC50: 600nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM83449(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)

IC50: 600nMAssay Description:Binding affinity against phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50091625(5-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-1H-indo...)

IC50: 630nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440085(CHEMBL2426092)

IC50: 710nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440057(CHEMBL2426097)

IC50: 770nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440072(CHEMBL2426067)

IC50: 780nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440074(CHEMBL2426065)

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440075(CHEMBL2425979)

IC50: 790nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440091(CHEMBL2426086)

IC50: 900nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50017028(8-(2-Methoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoli...)

IC50: 900nMAssay Description:Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to PCP receptorMore data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440077(CHEMBL2425977)

IC50: 910nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440081(CHEMBL2426096)

IC50: 950nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50242449(CHEMBL525025 | conantokin-G)

IC50: 1.00E+3nMAssay Description:Inhibition of rat NMDA NR2C receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...More data for this Ligand-Target Pair

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PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440058(CHEMBL2426100)

IC50: 1.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50079387(1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...)

IC50: 1.00E+3nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair

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PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440067(CHEMBL2426072 | CHEMBL2426073)

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440073(CHEMBL2426066)

IC50: 1.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440052(CHEMBL2426105)

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440076(CHEMBL2425978)

IC50: 1.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50009093(6-Chloro-3-ethoxycarbonylmethyl-1H-indole-2-carbox...)

IC50: 1.60E+3nMAssay Description:Compound was evaluated for in vitro inhibition of oocytes at NMDA receptorMore data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440063(CHEMBL2426077)

IC50: 1.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440062(CHEMBL2426078)

IC50: 2.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440059(CHEMBL2426082)

IC50: 2.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50001263(5,7-Dichloro-4-hydroxy-3-(4-hydroxy-phenyl)-1H-qui...)

IC50: 2.10E+3nMAssay Description:Compound was evaluated for in vitro inhibition of spinal cord at NMDA receptor.More data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440051(CHEMBL2425972)

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440070(CHEMBL2426068 | CHEMBL2426069)

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50054798((1S,2R)-2-(1-Amino-propyl)-1-phenyl-cyclopropaneca...)

IC50: 2.20E+3nMAssay Description:Concentration required to inhibit of N-methyl-D-aspartic acid (NMDA) receptor produced by oocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50054804((1S,2R)-2-(1-Amino-ethyl)-1-phenyl-cyclopropanecar...)

IC50: 2.30E+3nMAssay Description:Concentration required to inhibit of N-methyl-D-aspartic acid (NMDA) receptor produced by oocytesMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440078(CHEMBL2426101)

IC50: 2.50E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50017043(1-(4-Methoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoli...)

IC50: 2.50E+3nMAssay Description:Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to PCP receptorMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50004952(3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carbo...)

IC50: 2.70E+3nMAssay Description:Compound was evaluated for in vitro inhibition of cGMP cerebellar slice at NMDA receptor.More data for this Ligand-Target Pair

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PDB Reactome pathway
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440061(CHEMBL2424674)

IC50: 3.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50009106(3-Carboxymethyl-6-chloro-1H-indole-2-carboxylic ac...)

IC50: 3.20E+3nMAssay Description:Compound was evaluated for in vitro inhibition of oocytes at NMDA receptorMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440047(CHEMBL2425976)

IC50: 3.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Glutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL

BDBM50440053(CHEMBL2426104)

IC50: 3.60E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair