Compile Data Set for Download or QSAR
Report error Found 1275 of ic50 for UniProtKB: Q07869
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50391056(CHEMBL2088421)
Affinity DataIC50: 0.280nMAssay Description:Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50099491(cid_3392731 | CHEMBL21241 | 2-(4-{2-[3-Cyclohexyl-...)
Affinity DataIC50: 0.460nMAssay Description:Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50391057(CHEMBL2088422)
Affinity DataIC50: 0.590nMAssay Description:Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50099489(2-(4-{2-[1-(4-Cyclohexyl-butyl)-3-(2-methoxy-pheny...)
Affinity DataIC50: 1.90nMAssay Description:Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179830((S)-2-(4-(3-(2-chloro-4-cyclohexylphenoxy)propoxy)...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to human PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50013729(CHEMBL3264919)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50013730(CHEMBL3264920)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50013734(CHEMBL3264924)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179824((S)-2-(4-(3-(2-chloro-4-(trifluoromethoxy)phenoxy)...)
Affinity DataIC50: 3nMAssay Description:Binding affinity to human PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179833((S)-2-(4-(3-(2-chloro-4-(trifluoromethyl)phenoxy)p...)
Affinity DataIC50: 3nMAssay Description:Binding affinity to human PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM28802(2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...)
Affinity DataIC50: 97nM EC50:  4nMpH: 8.0 T: 2°CAssay Description:For hPPAR alpha, percentage inhibition was calculated relative to unlabeled GW2331, which was used as the active site-specific competitive binder. Fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50013735(CHEMBL3264925)
Affinity DataIC50: 4.60nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50212693(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50: 4.70nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50212693(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50: 4.70nMAssay Description:Displacement of [3H]2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenoxy)-2-methylbutanoic acid from human PPARalpha after 30 mins by SPA ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50212693(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50: 4.70nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179818(2-(4-(3-(2-chloro-4-(4-fluorophenoxy)phenoxy)propo...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to human PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM28681(cid_5281055 | [3H]rosiglitazone | CHEMBL121 | ROSI...)
Affinity DataIC50: 5nMAssay Description:In vitro binding affinity for human PPAR alpha in SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179826((R)-2-(4-(3-(2-chloro-4-(4-fluorophenoxy)phenoxy)p...)
Affinity DataIC50: 6nMAssay Description:Binding affinity to human PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50013736(CHEMBL3264926)
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50168554((R)-7-{3-[2-Chloro-4-(1,1-dimethyl-propyl)-phenoxy...)
Affinity DataIC50: 7nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50168554((R)-7-{3-[2-Chloro-4-(1,1-dimethyl-propyl)-phenoxy...)
Affinity DataIC50: 7nMAssay Description:In vitro binding affinity against human PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM28800(2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...)
Affinity DataIC50: 260nM EC50:  10nMpH: 8.0 T: 2°CAssay Description:For hPPAR alpha, percentage inhibition was calculated relative to unlabeled GW2331, which was used as the active site-specific competitive binder. Fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179836((S)-2-(4-(3-(2-chloro-4-(2,2,2-trifluoroethoxy)phe...)
Affinity DataIC50: 10nMAssay Description:Binding affinity to human PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50311792(4'-butoxy-3'-((2-fluoro-4-(trifluoromethyl)benzami...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at PPARalpha co-transfected with GAL4-PPAR fusion protein assessed as inhibition of TIPP703-induced response by luciferase report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135773(2-(4-{3-[1-(3,4-Dimethyl-benzyl)-4-methyl-5-oxo-4,...)
Affinity DataIC50: 12.0nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135773(2-(4-{3-[1-(3,4-Dimethyl-benzyl)-4-methyl-5-oxo-4,...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50013731(CHEMBL3264921)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135777(2-(4-{3-[1-(4-tert-Butyl-benzyl)-4-methyl-5-oxo-4,...)
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50168544((R)-7-[3-(2-Chloro-4-cyclohexyl-phenoxy)-propoxy]-...)
Affinity DataIC50: 15nMAssay Description:In vitro binding affinity against human PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135777(2-(4-{3-[1-(4-tert-Butyl-benzyl)-4-methyl-5-oxo-4,...)
Affinity DataIC50: 15nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50184274(2-(4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50: 16nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50168557((R)-7-[3-(2-Chloro-4-isobutyl-phenoxy)-propoxy]-2-...)
Affinity DataIC50: 16nMAssay Description:In vitro binding affinity against human PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50168557((R)-7-[3-(2-Chloro-4-isobutyl-phenoxy)-propoxy]-2-...)
Affinity DataIC50: 16nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135775(2-Methyl-2-(4-{3-[1-(4-methyl-benzyl)-5-oxo-4-prop...)
Affinity DataIC50: 16nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135775(2-Methyl-2-(4-{3-[1-(4-methyl-benzyl)-5-oxo-4-prop...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50184274(2-(4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50184274(2-(4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50: 16nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50508126(CHEMBL4457564)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at recombinant human PPARalpha assessed as inhibition of GW7647-induced receptor activation after overnight incubation by cell-ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50145719((S)-3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-et...)
Affinity DataIC50: 18.0nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50145719((S)-3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-et...)
Affinity DataIC50: 18nMAssay Description:Displacement of PPAR-alpha/delta agonist from human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50508137(CHEMBL4437146)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at recombinant human PPARalpha assessed as inhibition of GW7647-induced receptor activation after overnight incubation by cell-ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50508153(CHEMBL4549922)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at recombinant human PPARalpha assessed as inhibition of GW7647-induced receptor activation after overnight incubation by cell-ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135782(2-(4-{3-[1-(3-Methoxy-benzyl)-5-oxo-4-propyl-4,5-d...)
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50184261(2-(4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50: 19nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50184261(2-(4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50: 19nMAssay Description:Inhibition of PPAR alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50184261(2-(4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50: 19.0nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50135782(2-(4-{3-[1-(3-Methoxy-benzyl)-5-oxo-4-propyl-4,5-d...)
Affinity DataIC50: 19.0nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50063315(CHEMBL3398446)
Affinity DataIC50: 20nMAssay Description:Binding affinity to PPARalpha (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50152829(CHEMBL3780740)
Affinity DataIC50: 20nMAssay Description:Agonist activity at PPAR-alpha receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50145722((S)-2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-y...)
Affinity DataIC50: 21.0nMAssay Description:Agonist activity at PPARalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
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