Affinity DataIC50: 4nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of ALK2 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of ALK1 (unknown origin) expressed in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of BMP4-induced BMP receptor in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 186nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of BMP2-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of BMP4-induced BMP receptor in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology
Curated by ChEMBL
Massachusetts Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of BMP4-induced BMP receptor in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair