Compile Data Set for Download or QSAR
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Found 100 Enz. Inhib. hit(s) with all data for entry = 50039084
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat liver DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  9.73nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  22nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  42nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  78nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18245((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  170nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18245((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  210nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50030819((S)-2-(4-(2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)...)
Affinity DataIC50:  220nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50030820((S)-2-(4-((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)me...)
Affinity DataIC50:  220nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50:  220nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18795((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)
Affinity DataIC50:  380nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50:  460nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18245((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  540nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18795((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)
Affinity DataIC50:  900nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii TS at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18245((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  1.80E+3nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii TS at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  2.20E+3nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18795((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)
Affinity DataIC50:  2.30E+3nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50:  2.80E+3nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii TS at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  4.00E+3nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  5.40E+3nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50:  6.60E+3nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310330(2,4-Diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50:  9.50E+3nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310329(2,4-Diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]...)
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310329(2,4-Diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]...)
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310329(2,4-Diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]...)
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of rat liver DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310327(2,4-Diamino-5-methyl-6-(2',6'-dichlorophenylsulfan...)
Affinity DataIC50:  1.44E+4nMAssay Description:Inhibition of rat liver DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310331(2,4-Diamino-5-methyl-6-(2'-isopropyl-6'-methylphen...)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310332(2,4-Diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfa...)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310328(2,4-Diamino-5-methyl-6-(2',6'-dimethylphenylsulfan...)
Affinity DataIC50:  1.97E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310328(2,4-Diamino-5-methyl-6-(2',6'-dimethylphenylsulfan...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310334(2,4-Diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-...)
Affinity DataIC50:  2.03E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  2.05E+4nMAssay Description:Inhibition of rat liver DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18795((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)
Affinity DataIC50:  2.10E+4nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310331(2,4-Diamino-5-methyl-6-(2'-isopropyl-6'-methylphen...)
Affinity DataIC50:  2.34E+4nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310334(2,4-Diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-...)
Affinity DataIC50:  2.39E+4nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310337(2,4-Diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfa...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310331(2,4-Diamino-5-methyl-6-(2'-isopropyl-6'-methylphen...)
Affinity DataIC50:  2.43E+4nMAssay Description:Inhibition of rat liver DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310333(2,4-Diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-...)
Affinity DataIC50:  2.52E+4nMAssay Description:Inhibition of Pneumocystis carinii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310336(2,4-Diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-...)
Affinity DataIC50:  2.55E+4nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310327(2,4-Diamino-5-methyl-6-(2',6'-dichlorophenylsulfan...)
Affinity DataIC50:  2.55E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310338(CHEMBL596672 | N-[4-[(2,4-Diamino-5-methyl-furo[2,...)
Affinity DataIC50:  2.70E+4nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii TS at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50310333(2,4-Diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-...)
Affinity DataIC50:  2.84E+4nMAssay Description:Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  2.90E+4nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
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