Compile Data Set for Download or QSAR
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Found 38 Enz. Inhib. hit(s) with all data for entry = 50013014
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562134(CHEMBL4794518)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of N-terminal His-tagged p300 HAT (unknown origin) (1287 to 1666 residues) expressed in Escherichia coli using biotinylated H3(1-21) pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50553555(CHEMBL4758366)
Affinity DataIC50:  60nMAssay Description:Inhibition of GST-tagged CBP bromodomain (1082 to 1197 residue) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using SGRG-K(Ac)-GG-K ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM349058(2-[(E)-2-[(4R)-4-methyl- | US10206931, Example 11)
Affinity DataIC50:  180nMAssay Description:Inhibition of His-FLAG-tagged CBP ( 1082 to 1197 residues) (unknown origin) using H4-tetraAc-biotin as substrate incubated for 20 mins by AlphaLISA a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562132(CHEMBL4790788)
Affinity DataIC50:  320nMAssay Description:Inhibition of His-tagged CBP bromodomain (unknown origin) using H2N-ALREIRRYQK(Ac)STELLIRKLK-(biotin)-COOH as substrate preincubated for 30 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50528260(CHEMBL4457203)
Affinity DataIC50:  420nMAssay Description:Inhibition of N-terminal His/GST-tagged human p300 HAT (965 to 1810 residues) expressed in Sf9 insect cells using H3 peptide as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM349364((4R)-6-(1-tert-butylpyrazol-4- | US10206931, Examp...)
Affinity DataIC50:  470nMAssay Description:Inhibition of His-FLAG-tagged CBP ( 1082 to 1197 residues) (unknown origin) using H4-tetraAc-biotin as substrate incubated for 20 mins by AlphaLISA a...More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562137(CHEMBL4789343)
Affinity DataIC50:  500nMAssay Description:Inhibition of N-terminal GST-fused human P300 (1284 to1673 residues) catalytic domain expressed in sf9 insect cells using histone H3 and [acetyl-3H]-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562136(CHEMBL4752387)
Affinity DataIC50:  580nMAssay Description:Inhibition of N-terminal His/GST-tagged human p300 HAT (965 to 1810 residues) expressed in Sf9 insect cells using H3 peptide as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562135(CHEMBL4759868)
Affinity DataIC50:  690nMAssay Description:Inhibition of N-terminal His/GST-tagged human p300 HAT (965 to 1810 residues) expressed in Sf9 insect cells using H3 peptide as substrate in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562131(CHEMBL4751783)
Affinity DataIC50:  760nMAssay Description:Inhibition of His-tagged CBP bromodomain (unknown origin) using H2N-ALREIRRYQK(Ac)STELLIRKLK-(biotin)-COOH as substrate preincubated for 30 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562133(CHEMBL4758202)
Affinity DataIC50:  774nMAssay Description:Inhibition of human GST-tagged CBP BrD (1082 to 1197 residues) expressed in Escherichia coli BL21 (DE3) cells using N-C: SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50292332(2,3,9,10-Tetramethoxy-5,6-dihydro-isoquino[3,2-a]i...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of N-terminal His/GST-tagged human p300 HAT (965 to 1810 residues) expressed in Sf9 insect cells using H3 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50151658(CHEMBL3775671)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of P300 catalytic domain (unknown origin) using histone H3 and [acetyl-3H]-acetylcoenzyme A as substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346554(CHEMBL106011)
Affinity DataIC50:  2.49E+3nMAssay Description:Inhibition of N-terminal GST-tagged human CBP HAT(1319 to 1710 residues) expressed in Escherichia coli using histone H3 (1 to 21 residues) as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562130(CHEMBL4748922)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of GST-tagged CBP bromodomain (1082 to 1197 residue) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using SGRG-K(Ac)-GG-K ...More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50542044(CHEMBL4635386)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of N-terminal His-tagged p300 HAT (unknown origin) (1287 to 1666 residues) expressed in Escherichia coli using biotinylated H3(1-21) pepti...More data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346559(CHEMBL1795624)
Affinity DataIC50:  2.85E+3nMAssay Description:Inhibition of N-terminal GST-tagged human CBP HAT(1319 to 1710 residues) expressed in Escherichia coli using histone H3 (1 to 21 residues) as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50528245(CHEBI:9419 | taxodione)
Affinity DataIC50:  4.85E+3nMAssay Description:Inhibition of N-terminal His/GST-tagged human p300 HAT (965 to 1810 residues) expressed in Sf9 insect cells using H3 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346554(CHEMBL106011)
Affinity DataIC50:  5.35E+3nMAssay Description:Inhibition of N-terminal His-tagged human p300 HAT (1319 to 1710 residues) expressed in Escherichia coli using histone H3 (1 to 21 residues) as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346559(CHEMBL1795624)
Affinity DataIC50:  5.92E+3nMAssay Description:Inhibition of N-terminal His-tagged human p300 HAT (1319 to 1710 residues) expressed in Escherichia coli using histone H3 (1 to 21 residues) as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346554(CHEMBL106011)
Affinity DataIC50:  8.39E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged GCN5 HAT domain (362 to 837 residues) expressed in baculovirus infected Sf9 cells using histon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346554(CHEMBL106011)
Affinity DataIC50:  9.74E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PCAF HAT domain (493 to 657 residues) expressed in Escherichia coli (BL21 D3) using histone H3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50528254(CHEMBL4515219)
Affinity DataIC50:  5.75E+4nMAssay Description:Inhibition of human P300 (1284 to1673 residues) catalytic domain using histone H3 and [acetyl-3H]-acetylcoenzyme A as substrate incubated for 1 hr by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346559(CHEMBL1795624)
Affinity DataIC50:  8.74E+4nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged GCN5 HAT domain (362 to 837 residues) expressed in baculovirus infected Sf9 cells using histon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50346559(CHEMBL1795624)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PCAF HAT domain (493 to 657 residues) expressed in Escherichia coli (BL21 D3) using histone H3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50559314(CHEMBL4741587)
Affinity DataKd:  470nMAssay Description:Binding affinity to human His-Tev tagged EP300 expressed in bacterial expression system incubated for 30 mins by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50159140(CHEMBL3785648)
Affinity DataKd:  2.26E+4nMAssay Description:Binding affinity to human His-Tev tagged EP300 expressed in bacterial expression system incubated for 30 mins by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50559314(CHEMBL4741587)
Affinity DataKd:  230nMAssay Description:Binding affinity to human His-Tev tagged CBP expressed in bacterial expression system incubated for 30 mins by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50159140(CHEMBL3785648)
Affinity DataKd:  1.81E+4nMAssay Description:Binding affinity to human His-Tev tagged CBP expressed in bacterial expression system incubated for 30 mins by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM349364((4R)-6-(1-tert-butylpyrazol-4- | US10206931, Examp...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of NanoLuc tagged CBP bromodomain (unknown origin) expressed in HEK293 cells harboring Halo-tagged histone H3.3 by NanoBRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM349058(2-[(E)-2-[(4R)-4-methyl- | US10206931, Example 11)
Affinity DataEC50:  530nMAssay Description:Inhibition of NanoLuc tagged CBP bromodomain (unknown origin) expressed in HEK293 cells harboring Halo-tagged histone H3.3 by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  5.20E+3nMAssay Description:Binding affinity to human BRD4 bromodomain2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  850nMAssay Description:Binding affinity to human BRD4 bromodomain1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562129(CHEMBL4754613)
Affinity DataKd:  480nMAssay Description:Binding affinity to human BRD4 bromodomain1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50238255(CHEMBL3753333)
Affinity DataKd:  950nMAssay Description:Binding affinity to human BRD4 bromodomain1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  21nMAssay Description:Binding affinity to human CBP by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50238255(CHEMBL3753333)
Affinity DataKd:  320nMAssay Description:Binding affinity to human CBP by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50562129(CHEMBL4754613)
Affinity DataKd:  28nMAssay Description:Binding affinity to human CBP by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed