Found 87 of ph data with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataKi: 199nM ΔG°: -39.4kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataKi: 250nM ΔG°: -38.8kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataKi: 500nM ΔG°: -37.0kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 0.25nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
3D Structure (crystal)TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 0.800nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 0.870nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 1.10nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 1.30nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 1.30nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 1.70nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 2nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 2.20nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 2.95nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 3.10nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 3.80nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 5.13nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 5.20nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 5.37nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 5.75nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 5.89nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 6.5nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 8.13nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 8.32nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 9nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 12.6nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 16.2nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 17.8nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 18.2nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 19nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 22.4nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 23nMpH: 7.5Assay Description:Inhibition of the human PDE4 enzyme, using semi-purified enzyme from human U937 cells. The PDE4 enzyme was partially purified from human U937 myeloid...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 25nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 33.1nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 33.1nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 34.7nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 70.8nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 79nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 145nMpH: 7.4 T: 2°CAssay Description:PDE4B1 activity was inhibited by the compounds according to the invention in a modified SPA (scintillation proximity assay) test, supplied by Amersha...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 398nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: 631nMpH: 7.5 T: 2°CAssay Description:Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: <1.00E+3nMpH: 7.8 T: 2°CAssay Description:The test compound or water (control) is mixed with the human recombinant PDE4B1 enzyme (4.8 U) in a buffer consisting of 44.4 mM tris-HCl, 5.28 mM Mg...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: <1.00E+3nMpH: 7.8 T: 2°CAssay Description:The test compound or water (control) is mixed with the human recombinant PDE4B1 enzyme (4.8 U) in a buffer consisting of 44.4 mM tris-HCl, 5.28 mM Mg...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Human Biomolecular Research Institute
Human Biomolecular Research Institute
Affinity DataIC50: <1.00E+3nMpH: 7.8 T: 2°CAssay Description:The test compound or water (control) is mixed with the human recombinant PDE4B1 enzyme (4.8 U) in a buffer consisting of 44.4 mM tris-HCl, 5.28 mM Mg...More data for this Ligand-Target Pair
