Compile Data Set for Download or QSAR
maximum 50k data
Found 171 of ec50 data for polymerid = 10784
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249689(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  3.30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50164200(2,3,9,10-tetrafluoro-13-(5-fluoro-3,4-dihydroxy-6-...)
Affinity DataEC50:  6.40nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50164201(12-(6-aminomethyl-5,5-difluoro-3,4-dihydroxytetrah...)
Affinity DataEC50:  8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086563(CHEMBL135492 | NB-506 Analogue)
Affinity DataEC50:  8nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50164195(12-(6-aminomethyl-5-fluoro-3,4-dihydroxytetrahydro...)
Affinity DataEC50:  11.2nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249684(2,10-Dihydroxy-6-[(4-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  12nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50164199(3,9-difluoro-12-(5-fluoro-3,4,5-trihydroxy-6-hydro...)
Affinity DataEC50:  12.8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249688(2,10-Dihydroxy-6-{[2-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  16nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086567(CHEMBL133209 | NB-506 Analogue)
Affinity DataEC50:  17nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086571(CHEMBL135491 | NB-506 Analogue)
Affinity DataEC50:  17nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249676(2,10-Dihydroxy-6-[(quinolin-2-ylmethyl)amino]-13-(...)
Affinity DataEC50:  17nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50164197(3,9-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxym...)
Affinity DataEC50:  17.6nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249692(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  19nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249678(2,10-Dihydroxy-6-[(quinolin-4-ylmethyl)amino]-13-(...)
Affinity DataEC50:  20nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249686(2,10-Dihydroxy-6-[(3-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  20nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086565(CHEMBL135881 | NB-506 Analogue)
Affinity DataEC50:  20nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249687(2,10-Dihydroxy-6-{[3-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  22nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249691(2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  22nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249674(2,10-Dihydroxy-6-[(pyridin-4-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  22nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249673(2,10-Dihydroxy-6-[(pyridin-3-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  23nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249693(2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  25nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249668(6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyr...)
Affinity DataEC50:  25nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086557(CHEMBL334337 | NB-506 Analogue)
Affinity DataEC50:  25nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086560(CHEMBL338966 | NB-506 Analogue)
Affinity DataEC50:  26nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086576(CHEMBL334869 | NB-506 Analogue)
Affinity DataEC50:  26nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249690(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  27nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249696(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-4-yl]...)
Affinity DataEC50:  29nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249677(2,10-Dihydroxy-6-[(quinolin-3-ylmethyl)amino]-13-(...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249671(2,10-Dihydroxy-6-[(1H-pyrrol-2-ylmethyl)amino]-13-...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249670(6-[(3-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249695(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086559(CHEMBL135970 | NB-506 Analogue)
Affinity DataEC50:  30nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249672(2,10-Dihydroxy-6-[(pyridin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  30nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249697(2,10-Dihydroxy-6-({[2-(hydroxymethyl)pyridin-4-yl]...)
Affinity DataEC50:  31nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50164203(2,10-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxy...)
Affinity DataEC50:  32nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086575(CHEMBL132533 | NB-506 Analogue)
Affinity DataEC50:  32nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249685(2,10-Dihydroxy-6-{[4-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  34nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249694(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  35nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249675(2,10-Dihydroxy-6-[(pyrazin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  35nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083604(2,9-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylami...)
Affinity DataEC50:  37nMAssay Description:In vitro inhibition of Topoisomerase I-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249669(6-[(2-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  38nMAssay Description:Inhibition of human DNA topoisomerase 1-mediated DNA cleavage assessed as relaxation of supercoiled pBR322 plasmid DNA after 15 mins by densitometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50142927(12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahy...)
Affinity DataEC50:  38.4nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086562(CHEMBL334360 | NB-506 Analogue)
Affinity DataEC50:  40nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086566(CHEMBL336626 | NB-506 Analogue)
Affinity DataEC50:  42nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50036133(7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1...)
Affinity DataEC50:  50nMAssay Description:Effective concentration against DNA topoisomerase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086570(CHEMBL435191 | Edotecarin | NB-506 Analogue)
Affinity DataEC50:  51nMAssay Description:Inhibition of topoisomerase-1 (unknown origin) using pBR 322 DNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50086570(CHEMBL435191 | Edotecarin | NB-506 Analogue)
Affinity DataEC50:  51nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083600(2,10-dihydroxy-6-(2-hydroxy-1-hydroxymethylethylam...)
Affinity DataEC50:  51nMAssay Description:In vitro inhibition of Topoisomerase I-mediated DNA cleavage using supercoiled pBR322 plasmid DNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50076926(1,11-dihydroxy-5,7-dioxo-6-phenylcarboxamido-12-(3...)
Affinity DataEC50:  52nMAssay Description:In vitro activity against topoisomerase-I mediated cleavage of supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataEC50:  54nMAssay Description:Inhibition of topoisomerase-1 in human U251 cells assessed as inhibition of hypoxia-induced HIF-1alpha accumulation in nuclear extract after 6 to 24 ...More data for this Ligand-Target Pair
Displayed 1 to 50 (of 171 total ) | Next | Last >>
Jump to: