BDBM50086570 CHEMBL435191::Edotecarin::NB-506 Analogue
SMILES OCC(CO)NN1C(=O)c2c(C1=O)c1c3ccc(O)cc3n([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c1c1[nH]c3cc(O)ccc3c21
InChI Key InChIKey=QMVPQBFHUJZJCS-NTKFZFFISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50086570
Affinity DataEC50: 51nMAssay Description:Inhibitory effect on topoisomerase-I mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
Affinity DataEC50: 51nMAssay Description:Inhibition of topoisomerase-1 (unknown origin) using pBR 322 DNA as substrateMore data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory effect on protein kinase C using histone II-As as substrateMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Tested for inhibitory effect on topoisomerase-2 mediated DNA cleavage using super coiled pBR322 plasmid DNAMore data for this Ligand-Target Pair