Compile Data Set for Download or QSAR
Report error Found 4997 Enz. Inhib. hit(s) with Target = 'Sodium-dependent noradrenaline transporter'
LigandPNGBDBM35233(3-(phenylsulfonyl)-1H-indole, 27a)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM35235(3-(phenylsulfonyl)-1H-indole, 27b)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM35236(3-(phenylsulfonyl)-1H-indole, 26a)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM35237(3-(phenylsulfonyl)-1H-indole, 26b)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM35238(3-(phenylsulfonyl)-1H-indole, 28a)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM35239(3-(phenylsulfonyl)-1H-indole, 28b)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50299788(4-(2-(3-fluorophenoxy)phenyl)piperidine | CHEMBL58...)
Affinity DataEC50:  21nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  28nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50299798(4-(2-(3-chlorophenoxy)phenyl)piperidine | CHEMBL57...)
Affinity DataEC50:  49nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50299797(1-(2-(benzyloxy)phenyl)piperazine | CHEMBL582928)
Affinity DataEC50:  83nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50299792(4-(3-fluoro-2-phenoxyphenyl)piperidine | CHEMBL583...)
Affinity DataEC50:  358nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at NETMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50309519(2-(2-chloro-6-fluorophenoxy)-3-(piperidin-4-yl)pyr...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at NETMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataKd:  0.830nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataKd:  1.40nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50333434(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)az...)
Affinity DataEC50:  239nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50333433(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)az...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50333448(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)py...)
Affinity DataEC50:  97nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022723((2S)-1-phenylpropan-2-amine | (S)-amphetamine | (+...)
Affinity DataEC50:  7.10nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET cloned in rat brain synaptosome by scintillation countingMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50069446((1S,2R)-1-Cyclohexyl-3-dimethylamino-2-(4-methoxy-...)
Affinity DataKd:  1.80E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069445((1R,2R)-3-Dimethylamino-1,2-diphenyl-propan-1-ol; ...)
Affinity DataKd:  2.25E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069443((1R,2R)-3-Amino-1,2-diphenyl-propan-1-ol; hydrochl...)
Affinity DataKd:  1.25E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366567(ATOMOXETINE)
Affinity DataKd:  2nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50069442((2R,3R)-1-Amino-4,4-dimethyl-2-naphthalen-2-yl-pen...)
Affinity DataKd:  55nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKd:  4.79E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataKd:  420nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069452((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...)
Affinity DataKd:  3.58E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069447(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-e...)
Affinity DataKd:  360nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069449((2R,3R)-1-Dimethylamino-4,4-dimethyl-2-naphthalen-...)
Affinity DataKd:  30nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069454((1S,2R)-3-Amino-1-cyclohexyl-2-(4-methoxy-phenyl)-...)
Affinity DataKd:  1.54E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069444((1R,2R)-3-Amino-2-phenyl-1-(2,4,6-trimethyl-phenyl...)
Affinity DataKd:  2.25E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataKd:  40nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069453((1R,2R)-3-Dimethylamino-2-naphthalen-2-yl-1-phenyl...)
Affinity DataKd:  44nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069450((2R,3R)-1-Dimethylamino-4,4-dimethyl-2-phenyl-pent...)
Affinity DataKd:  3.43E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50025691(2-(2-Ethoxy-phenoxymethyl)-morpholine(viloxazine) ...)
Affinity DataKd:  155nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKd:  1.06E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069448((1R,2R)-3-Amino-2-naphthalen-2-yl-1-phenyl-propan-...)
Affinity DataKd:  21nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataKd:  240nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22417(LY 94939 | Nisoxetine Inhibitor | Nisoxetine | LY1...)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to human wild type NET expressed in african green monkey COS1 cellsMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50459929(CHEMBL4228171)
Affinity DataKd:  42nMAssay Description:Binding affinity to human NET expressed in HEK293 cells after 60 mins in presence of [3H]imipramine by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475951(CHEMBL3988463)
Affinity DataEC50:  1.82E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET in COS7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50475952(CHEMBL2371930)
Affinity DataEC50:  1.38E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET in COS7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50237600(CHEMBL4071867)
Affinity DataEC50: >1.00E+4nMAssay Description:Enhancing of [3H]mazindol binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50010588(DL-(3,4-Methylenedioxy)methamphetamine | N-Methyl-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Binding affinity to human NET expressed in HEK293 cells assessed as induction of [3H]MPP+ release by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50235079(CHEMBL4103112)
Affinity DataEC50:  827nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50236726(CHEMBL4092411)
Affinity DataEC50:  1.52E+3nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50235120(CHEMBL4087670)
Affinity DataEC50:  26nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50235078(CHEMBL4092912)
Affinity DataEC50:  1.39E+3nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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