Compile Data Set for Download or QSAR
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Found 67 Enz. Inhib. hit(s) with all data for entry = 50009344
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082343(3-(4-Chloro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082353(3-(3,4-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082356(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-p-toly...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082349(3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082348(3-(2,4-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082343(3-(4-Chloro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082346(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-phenox...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082345(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-m-toly...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082354(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-o-toly...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082352(3-(3,5-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082344(3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082346(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-phenox...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082356(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-p-toly...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082352(3-(3,5-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082348(3-(2,4-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082351(3-(4-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082353(3-(3,4-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082349(3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082350(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-phenyl...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082354(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-o-toly...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082351(3-(4-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082345(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-m-toly...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082356(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-p-toly...)
Affinity DataIC50: <300nMAssay Description:In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082355(3-Benzyl-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082345(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-m-toly...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082348(3-(2,4-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50: <300nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082345(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-m-toly...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082343(3-(4-Chloro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082344(3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082354(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-o-toly...)
Affinity DataIC50: <300nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082357(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-phenyl...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082347(3-Benzoyl-4-(4-methanesulfonyl-phenyl)-5,5-dimethy...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082351(3-(4-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50: <700nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082347(3-Benzoyl-4-(4-methanesulfonyl-phenyl)-5,5-dimethy...)
Affinity DataIC50:  800nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082349(3-(3-Fluoro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082352(3-(3,5-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082353(3-(3,4-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082348(3-(2,4-Difluoro-phenoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50: <1.20E+3nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1; 1-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082350(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-phenyl...)
Affinity DataIC50:  1.50E+3nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082343(3-(4-Chloro-phenoxy)-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  1.80E+3nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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