Compile Data Set for Download or QSAR
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Found 12 Enz. Inhib. hit(s) with all data for entry = 50010514
TargetLanosterol synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601(CHEMBL25405 | [4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)...)
Affinity DataIC50:  35nMAssay Description:Compound was tested for its inhibition against human OSC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095598(CHEMBL70223 | [4-(4-Bromo-benzenesulfonyl)-piperaz...)
Affinity DataIC50:  37nMAssay Description:Compound was tested for its inhibition against human OSC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095601(CHEMBL25405 | [4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)...)
Affinity DataIC50:  58nMAssay Description:In vitro percent inhibitory activityof the compound against rat microsomal OSC enzyme at 1 microM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095600(CHEMBL148268 | [4-(4-Iodo-benzenesulfonyl)-piperaz...)
Affinity DataIC50:  82nMAssay Description:In vitro inhibitory activityof the compound against rat microsomal 2,3-Oxidosqualene cyclase-Lanosterol synthase (OSC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095599(CHEMBL25285 | {4-[4-(4,5-Dihydro-oxazol-2-yl)-benz...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibitory activityof the compound against rat microsomal 2,3-Oxidosqualene lanosterol cyclase (OSC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095597(CHEMBL359233 | [4-(4-Bromo-benzenesulfonyl)-pipera...)
Affinity DataIC50:  112nMAssay Description:Compound was tested for its inhibition against human OSC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095598(CHEMBL70223 | [4-(4-Bromo-benzenesulfonyl)-piperaz...)
Affinity DataIC50:  116nMAssay Description:Compound was tested for its inhibition against rat OSC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095595((4-Benzenesulfonyl-piperazin-1-yl)-(3,4,5,6-tetrah...)
Affinity DataIC50:  143nMAssay Description:Compound was tested for its inhibition against human OSC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095596(CHEMBL70222 | [4-(4-Bromo-benzenesulfonyl)-piperaz...)
Affinity DataIC50:  161nMAssay Description:Compound was tested for its inhibition against human OSC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095596(CHEMBL70222 | [4-(4-Bromo-benzenesulfonyl)-piperaz...)
Affinity DataIC50:  228nMAssay Description:In vitro inhibitory activityof the compound against rat microsomal 2,3-Oxidosqualene lanosterol cyclase (OSC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095595((4-Benzenesulfonyl-piperazin-1-yl)-(3,4,5,6-tetrah...)
Affinity DataIC50:  326nMAssay Description:In vitro inhibitory activityof the compound against rat microsomal 2,3-Oxidosqualene lanosterol cyclase (OSC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50095597(CHEMBL359233 | [4-(4-Bromo-benzenesulfonyl)-pipera...)
Affinity DataIC50:  398nMAssay Description:Compound was tested for its inhibition against rat OSC enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed