Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 2202
TargetDihydrofolate reductase(Yeast)
Gsk

LigandPNGBDBM18043(CHEMBL318721 | 5-(pentan-3-yl)-5,10,12-triazatricy...)
Affinity DataIC50: 4nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
Gsk

LigandPNGBDBM18043(CHEMBL318721 | 5-(pentan-3-yl)-5,10,12-triazatricy...)
Affinity DataIC50: 6.60nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Yeast)
Gsk

LigandPNGBDBM18047(5-[(4-tert-butylphenyl)sulfanyl]quinazoline-2,4-di...)
Affinity DataIC50: 8nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Yeast)
Gsk

LigandPNGBDBM18046(CHEMBL83547 | 5-((4-methylphenyl)thio)-quinazoline...)
Affinity DataIC50: 23nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Yeast)
Gsk

LigandPNGBDBM18045(5-(phenylsulfanyl)quinazoline-2,4-diamine | 5-(PHE...)
Affinity DataIC50: 34nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Yeast)
Gsk

LigandPNGBDBM18048(5-{[4-(morpholin-4-yl)phenyl]sulfanyl}quinazoline-...)
Affinity DataIC50: 130nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
Gsk

LigandPNGBDBM18045(5-(phenylsulfanyl)quinazoline-2,4-diamine | 5-(PHE...)
Affinity DataIC50: 620nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Gsk

LigandPNGBDBM18046(CHEMBL83547 | 5-((4-methylphenyl)thio)-quinazoline...)
Affinity DataIC50: 940nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Gsk

LigandPNGBDBM18047(5-[(4-tert-butylphenyl)sulfanyl]quinazoline-2,4-di...)
Affinity DataIC50: 2.00E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Gsk

LigandPNGBDBM18048(5-{[4-(morpholin-4-yl)phenyl]sulfanyl}quinazoline-...)
Affinity DataIC50: 7.00E+4nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed