Compile Data Set for Download or QSAR
maximum 50k data
Found 47 Enz. Inhib. hit(s) with all data for entry = 50011361
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105748(4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105762(4-[4-(4-Fluoro-phenyl)-5-(2-phenylamino-pyrimidin-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105746(CHEMBL318892 | {4-[5-(4-Fluoro-phenyl)-3-(1-methyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JNK2beta2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105743(4-[3-(1-Benzyl-piperidin-4-yl)-5-(4-fluoro-phenyl)...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105763(CHEMBL420081 | D3RKN_10 | Ethyl-{4-[5-(4-fluoro-ph...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >10nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >10nMAssay Description:Inhibition of p56 Lck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105751(4-[4-(4-Fluoro-phenyl)-5-(2-phenoxy-pyrimidin-4-yl...)
Affinity DataIC50:  12nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50:  17nMAssay Description:Inhibition of PKC-beta2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of p56 Lck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105761(4-[4-(4-Fluoro-phenyl)-5-(2-methylamino-pyrimidin-...)
Affinity DataIC50:  18nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15239(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50:  19nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50:  19nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >20nMAssay Description:Inhibition of JNK 2 beta2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15239(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50:  20nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50099374(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  20nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105760(CHEMBL419149 | {4-[5-(4-Fluoro-phenyl)-3-piperidin...)
Affinity DataIC50:  27nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105753(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataIC50:  33nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50:  34nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105759(4-{5-(4-Fluoro-phenyl)-3-[1-(2,2,2-trifluoro-ethyl...)
Affinity DataIC50:  42nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105754(Benzyl-{4-[5-(4-fluoro-phenyl)-3-(1-methyl-piperid...)
Affinity DataIC50:  45nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50: >50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50: >50nMAssay Description:Inhibition of cdc2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >50nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >50nMAssay Description:Inhibition of cRaf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50: >50nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50: >50nMAssay Description:Inhibition of cRaf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105755(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  53nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105744(2-{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-...)
Affinity DataIC50:  53nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105741(4-[5-(4-Fluoro-phenyl)-3-(2,2,6,6-tetramethyl-pipe...)
Affinity DataIC50:  58nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105764(2-Ethoxy-4-[5-(4-fluoro-phenyl)-3-piperidin-4-yl-3...)
Affinity DataIC50:  79nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50:  83nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105742(4-[4-(4-Fluoro-phenyl)-5-(2-methoxy-pyrimidin-4-yl...)
Affinity DataIC50:  83nMAssay Description:Inhibition of PKCalpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105765(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataIC50:  83nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50:  83nMAssay Description:Inhibition of PKCalpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105750(4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)...)
Affinity DataIC50:  86nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105752(CHEMBL329447 | D3RKN_62 | {4-[5-(4-Fluoro-phenyl)-...)
Affinity DataIC50:  100nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50: >100nMAssay Description:Inhibition of cdc2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105757(4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataIC50:  160nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105749(4-[5-(4-Fluoro-phenyl)-3-(1-isopropyl-piperidin-4-...)
Affinity DataIC50:  170nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105756(4-[5-(4-Fluoro-phenyl)-3-isopropyl-3H-imidazol-4-y...)
Affinity DataIC50:  170nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105747(4-[5-(4-Fluoro-phenyl)-3-(tetrahydro-pyran-4-yl)-3...)
Affinity DataIC50:  230nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105758(4-[3-(1,1-Dioxo-hexahydro-1lambda*6*-thiopyran-4-y...)
Affinity DataIC50:  390nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50072402(4-[5-(4-Fluoro-phenyl)-3-(3-morpholin-4-yl-propyl)...)
Affinity DataIC50:  480nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50105745(CHEMBL329469 | {4-[5-(4-Fluoro-phenyl)-3-(1-methyl...)
Affinity DataIC50:  610nMAssay Description:Inhibition against Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed