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Found 30 Enz. Inhib. hit(s) with all data for entry = 50000213
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM30707(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Affinity DataIC50:  11nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50:  14nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003039(2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...)
Affinity DataIC50:  14nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003039(2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...)
Affinity DataIC50:  41nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM30707(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Affinity DataIC50:  49nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003036(CHEMBL412876 | Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...)
Affinity DataIC50:  63nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003038(CHEMBL26427 | Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...)
Affinity DataIC50:  81nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003038(CHEMBL26427 | Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003039(2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...)
Affinity DataIC50:  110nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM30707(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Affinity DataIC50:  130nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003036(CHEMBL412876 | Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...)
Affinity DataIC50:  150nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003036(CHEMBL412876 | Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...)
Affinity DataIC50:  220nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM30707(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Affinity DataIC50:  250nMAssay Description:Binding affinity of the compound towards 5-hydroxytryptamine 1C receptor using [3H]-mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003039(2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...)
Affinity DataIC50:  610nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50:  800nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003040(CHEMBL122860 | Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...)
Affinity DataIC50:  920nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003038(CHEMBL26427 | Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003040(CHEMBL122860 | Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...)
Affinity DataIC50:  1.20E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003040(CHEMBL122860 | Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...)
Affinity DataIC50:  1.20E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM30707(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Affinity DataIC50:  1.80E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003036(CHEMBL412876 | Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...)
Affinity DataIC50:  1.90E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003036(CHEMBL412876 | Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...)
Affinity DataIC50:  1.90E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003039(2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...)
Affinity DataIC50:  2.20E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003040(CHEMBL122860 | Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1C receptor in pig choroid plexus using [3H]-mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50:  4.20E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003037(2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50:  5.30E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003038(CHEMBL26427 | Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...)
Affinity DataIC50:  5.40E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003040(CHEMBL122860 | Dimethyl-[2-(1,6,7,8-tetrahydro-pyr...)
Affinity DataIC50:  5.90E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor in rat anterior cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50003038(CHEMBL26427 | Dimethyl-[2-(3-methyl-3,7,8,9-tetrah...)
Affinity DataIC50:  9.30E+3nMAssay Description:Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed