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Found 90 Enz. Inhib. hit(s) with all data for entry = 50015111
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151638(8''-chloro-5''-(5-hydroxy-1,2,4-oxadiazol-3-ylmeth...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151635(8''-chloro-5''-(1H-1,2,3,4-tetraazol-5-ylmethoxy)s...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151640(8''-chloro-5''-methoxyspiro[cyclohexane-1,4''-(1''...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151609(5'',8''-dichlorospiro[cyclohexane-1,4''-(1'',2'',3...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151634(5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151644(CHEMBL359890 | ethyl 5-[8''-chloro-2''-oxospiro[cy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151649(8''-chloro-5''-hydroxyspiro[cyclohexane-1,4''-(1''...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151636(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151631(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151645(8''-chloro-5''-[2-(1,4-oxazinan-4-yl)ethoxy]spiro[...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151641(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151630(2-{2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151647(8''-chloro-5''-(2-hydroxyethoxy)spiro[cyclohexane-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151646(8''-chloro-5''-methylspiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151648(8''-chloro-5''-(2-dimethylaminoethoxy)spiro[cycloh...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151628(8''-chlorospiro[cyclohexane-1,4''-(1'',2'',3'',4''...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151633(8''-chloro-5''-(2-hydroxy-3-methylaminopropoxy)spi...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151635(8''-chloro-5''-(1H-1,2,3,4-tetraazol-5-ylmethoxy)s...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151635(8''-chloro-5''-(1H-1,2,3,4-tetraazol-5-ylmethoxy)s...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human PDE1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151632(8''-chloro-5''-(3-dimethylamino-2-hydroxypropoxy)s...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151638(8''-chloro-5''-(5-hydroxy-1,2,4-oxadiazol-3-ylmeth...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151636(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151638(8''-chloro-5''-(5-hydroxy-1,2,4-oxadiazol-3-ylmeth...)
Affinity DataIC50:  820nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151642(8''-chloro-5''-(2-methylaminoethoxy)spiro[cyclohex...)
Affinity DataIC50:  960nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151644(CHEMBL359890 | ethyl 5-[8''-chloro-2''-oxospiro[cy...)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151639(5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151634(5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151637(8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclo...)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151634(5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151643(5''-[2-(2-aminoethoxy)ethoxy]-8''-chlorospiro[cycl...)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of human PDE7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151631(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151636(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  2.41E+3nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151644(CHEMBL359890 | ethyl 5-[8''-chloro-2''-oxospiro[cy...)
Affinity DataIC50:  2.98E+3nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151648(8''-chloro-5''-(2-dimethylaminoethoxy)spiro[cycloh...)
Affinity DataIC50:  3.28E+3nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151641(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  4.76E+3nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151631(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  5.86E+3nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151645(8''-chloro-5''-[2-(1,4-oxazinan-4-yl)ethoxy]spiro[...)
Affinity DataIC50:  7.35E+3nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151639(5''-(2-aminoethoxy)-8''-chlorospiro[cyclohexane-1,...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151647(8''-chloro-5''-(2-hydroxyethoxy)spiro[cyclohexane-...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151634(5-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151635(8''-chloro-5''-(1H-1,2,3,4-tetraazol-5-ylmethoxy)s...)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151633(8''-chloro-5''-(2-hydroxy-3-methylaminopropoxy)spi...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151647(8''-chloro-5''-(2-hydroxyethoxy)spiro[cyclohexane-...)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151636(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  1.27E+4nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151630(2-{2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1...)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151641(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151648(8''-chloro-5''-(2-dimethylaminoethoxy)spiro[cycloh...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151638(8''-chloro-5''-(5-hydroxy-1,2,4-oxadiazol-3-ylmeth...)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of human PDE3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151637(8''-chloro-5''-(3-dimethylaminopropoxy)spiro[cyclo...)
Affinity DataIC50:  2.37E+4nMAssay Description:Inhibition of human PDE4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151645(8''-chloro-5''-[2-(1,4-oxazinan-4-yl)ethoxy]spiro[...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of human PDE1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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