Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50017236
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179351BDBM50179351((2-chloro-3-methyl-4H-thieno[3,2-b]pyrrol-5-yl)(4-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22566BDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133018BDBM50133018((4,5-dichloro-1H-indol-2-yl)(4-methylpiperazin-1-y...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179340BDBM50179340((5-fluoro-4-methyl-1H-benzoimidazol-2-yl)(4-methyl...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50132999BDBM50132999((7-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133005BDBM50133005((5-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133004BDBM50133004((7-amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133011BDBM50133011((5,7-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133019BDBM50133019((5,7-difluoro-1H-indol-2-yl)(4-methylpiperazin-1-y...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133001BDBM50133001((5-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50132996BDBM50132996((5-Fluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133020BDBM50133020((1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone |...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179343BDBM50179343((5-fluoro-1H-benzoimidazol-2-yl)(4-methylpiperazin...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133016BDBM50133016((7-Chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179349BDBM50179349((4-methylpiperazin-1-yl)-(3-methyl-4H-thieno[3,2-b...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133007BDBM50133007((5-hydroxy-1H-indol-2-yl)(4-methylpiperazin-1-yl)m...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179346BDBM50179346((4-chloro-6-methyl-1H-benzoimidazol-2-yl)(4-methyl...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179345BDBM50179345((2-chloro-6H-thieno[2,3-b]pyrrol-5-yl)(4-methylpip...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179335BDBM50179335((5-chloro-1H-benzoimidazol-2-yl)(4-methylpiperazin...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179348BDBM50179348((5-fluoro-4-methyl-1H-indol-2-yl)-(4-methylpiperaz...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179350BDBM50179350((4-methyl-1H-benzoimidazol-2-yl)(4-methylpiperazin...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133008BDBM50133008((5,7-Dimethyl-1H-indol-2-yl)-(4-methyl-piperazin-1...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133009BDBM50133009((4-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179352BDBM50179352((7-chloro-5-methyl-1H-indol-2-yl)(4-methylpiperazi...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179353BDBM50179353((1H-benzoimidazol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133002BDBM50133002((1H-Indol-2-yl)-piperazin-1-yl-methanone | (1H-ind...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179344BDBM50179344((2-chloro-4H-thieno[3,2-b]pyrrol-5-yl)(4-methylpip...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133017BDBM50133017((5-methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179337BDBM50179337((4,5-difluoro-1H-benzoimidazol-2-yl)(4-methylpiper...)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133015BDBM50133015((7-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)met...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179336BDBM50179336((4-methylpiperazin-1-yl)(6H-thieno[2,3-b]pyrrol-5-...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179341BDBM50179341((4-methylpiperazin-1-yl)(4H-thieno[3,2-b]pyrrol-5-...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179339BDBM50179339((4,6-dichloro-1H-benzoimidazol-2-yl)(4-methylpiper...)
Affinity DataKi:  136nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133006BDBM50133006((6-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-...)
Affinity DataKi:  147nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179347BDBM50179347((5-trifluoromethyl-1H-indol-2-yl)-(4-methyl-pipera...)
Affinity DataKi:  412nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179342BDBM50179342((4-methylpiperazin-1-yl)(5-trifluoromethyl-1H-benz...)
Affinity DataKi:  427nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179354BDBM50179354((5-methyl-1H-benzoimidazol-2-yl)(4-methylpiperazin...)
Affinity DataKi:  528nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50132997BDBM50132997((5-Methoxy-1H-indol-2-yl)-(4-methyl-piperazin-1-yl...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22566BDBM22566(CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...)
Affinity DataKi:  5.13E+3nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50133002BDBM50133002((1H-Indol-2-yl)-piperazin-1-yl-methanone | (1H-ind...)
Affinity DataKi:  9.00E+3nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179335BDBM50179335((5-chloro-1H-benzoimidazol-2-yl)(4-methylpiperazin...)
Affinity DataKi:  1.41E+4nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed