Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50017561
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  2nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  3nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  5nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataKi:  5nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataKi:  7nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183787((S)-1-((2S,3R)-4-(hydroxyamino)-3-(hydroxymethyl)-...)
Affinity DataKi:  8nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataKi:  8nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183787((S)-1-((2S,3R)-4-(hydroxyamino)-3-(hydroxymethyl)-...)
Affinity DataKi:  10nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataKi:  11nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  19nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183787((S)-1-((2S,3R)-4-(hydroxyamino)-3-(hydroxymethyl)-...)
Affinity DataKi:  23nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataKi:  25nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataIC50: 48nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  55nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  56nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  57nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  66nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  83nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  187nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  213nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataKi:  230nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataKi:  300nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183781((S)-1-((2S,3S)-2-(4-chlorophenyl)-3-(hydroxycarbam...)
Affinity DataIC50: 316nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  321nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183783((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataIC50: 484nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183785((S)-1-((2S,3S)-3-(hydroxycarbamoyl)-2-(4-methoxyph...)
Affinity DataIC50: 836nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183786((2R,3S)-N-hydroxy-2-(hydroxymethyl)-3-(4-methoxyph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM30344(Trocade | Cipemastat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183787((S)-1-((2S,3R)-4-(hydroxyamino)-3-(hydroxymethyl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed