Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 1804
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14192BDBM14192(3-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}a...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14208BDBM14208(3-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 13534BDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14209BDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAromatase(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14209BDBM14209(4-(4-{[7-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 1nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of poly(Glu:Tyr) by purified recombinant human FLT3. The extent of phospho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14201BDBM14201(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-phenyl-7H-p...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14207BDBM14207(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-2-...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14203BDBM14203(7-(3-methoxyphenyl)-N-[3-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14191BDBM14191(N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14197BDBM14197(7-(3-methanesulfonylphenyl)-N-[4-(4-methylpiperazi...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14200BDBM14200(7-(3-methanesulfonylphenyl)-N-[3-(4-methylpiperazi...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14205BDBM14205(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14199BDBM14199(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14193BDBM14193(4-[4-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-y...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14202BDBM14202(3-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14196BDBM14196(N-[4-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14195BDBM14195(7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50: 18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14198BDBM14198(7-(2,3-dihydro-1H-inden-2-yl)-N-[4-(4-methylpipera...)
Affinity DataIC50: 18nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14194BDBM14194(7-{bicyclo[2.2.1]heptan-2-yl}-N-[4-(4-methylpipera...)
Affinity DataIC50: 29nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14204BDBM14204(N-[3-(4-methylpiperazin-1-yl)phenyl]-7-[3-(propan-...)
Affinity DataIC50: 29nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14189BDBM14189(7-cyclohexyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-...)
Affinity DataIC50: 31nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14194BDBM14194(7-{bicyclo[2.2.1]heptan-2-yl}-N-[4-(4-methylpipera...)
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14210BDBM14210(N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quin...)
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14189BDBM14189(7-cyclohexyl-N-[4-(4-methylpiperazin-1-yl)phenyl]-...)
Affinity DataIC50: 47nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14190BDBM14190(7-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-7H-pyrro...)
Affinity DataIC50: 49nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14191BDBM14191(N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4...)
Affinity DataIC50: 110nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14195BDBM14195(7-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50: 340nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14192BDBM14192(3-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}a...)
Affinity DataIC50: 350nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14190BDBM14190(7-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-7H-pyrro...)
Affinity DataIC50: 600nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetAurora kinase A(Mouse)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14206BDBM14206(N-cyclopentyl-3-(2-{[3-(4-methylpiperazin-1-yl)phe...)
Affinity DataIC50: 820nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14193BDBM14193(4-[4-({7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14196BDBM14196(N-[4-(4-methylpiperazin-1-yl)phenyl]-7-(pyridin-3-...)
Affinity DataIC50: 1.40E+3nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14197BDBM14197(7-(3-methanesulfonylphenyl)-N-[4-(4-methylpiperazi...)
Affinity DataIC50: 2.00E+3nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 14198BDBM14198(7-(2,3-dihydro-1H-inden-2-yl)-N-[4-(4-methylpipera...)
Affinity DataIC50: 2.10E+3nMAssay Description:The compounds were tested for their ability to inhibit the phosphorylation of serine 10 of histone-H3 by purified recombinant murine Aurora-A enzyme....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed