Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50018673
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197982BDBM50197982(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 6nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197996BDBM50197996(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 9nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197988BDBM50197988(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 30nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197982BDBM50197982(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197984BDBM50197984((S)-2-{3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...)
Affinity DataIC50: 43nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197978BDBM50197978(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 44nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197988BDBM50197988(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197993BDBM50197993((S)-2-{3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...)
Affinity DataIC50: 62nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197995BDBM50197995((S)-2-{4-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...)
Affinity DataIC50: 63nMAssay Description:Inhibition of CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197981BDBM50197981(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 66nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197984BDBM50197984((S)-2-{3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...)
Affinity DataIC50: 68nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197999BDBM50197999(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 74nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197996BDBM50197996(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 83nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197991BDBM50197991(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 107nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197980BDBM50197980(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 108nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197993BDBM50197993((S)-2-{3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...)
Affinity DataIC50: 118nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197978BDBM50197978(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 154nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197989BDBM50197989(4-(3-(3-chlorophenyl)-1-(naphthalen-2-yl)-1H-pyraz...)
Affinity DataIC50: 168nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197999BDBM50197999(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 178nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197995BDBM50197995((S)-2-{4-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...)
Affinity DataIC50: 185nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50198000BDBM50198000(N-(5-(diethylamino)pentan-2-yl)-4-(1-(naphthalen-2...)
Affinity DataIC50: 207nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197980BDBM50197980(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 209nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197980BDBM50197980(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 220nMAssay Description:Inhibition of CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197995BDBM50197995((S)-2-{4-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...)
Affinity DataIC50: 221nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197991BDBM50197991(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 225nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197981BDBM50197981(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 280nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197983BDBM50197983(4-(3-(4-chlorophenyl)-1-(naphthalen-2-yl)-1H-pyraz...)
Affinity DataIC50: 442nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197985BDBM50197985(N-(5-(diethylamino)pentan-2-yl)-4-(3-(3-fluorophen...)
Affinity DataIC50: 522nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197992BDBM50197992(4-(3-(3,5-bis(trifluoromethyl)phenyl)-1-(naphthale...)
Affinity DataIC50: 634nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197977BDBM50197977(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 1.12E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197979BDBM50197979(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 1.23E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197977BDBM50197977(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197982BDBM50197982(3-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of CCR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50198001BDBM50198001(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197998BDBM50197998(N-(5-(diethylamino)pentan-2-yl)-4-(3-(3-methoxyphe...)
Affinity DataIC50: 2.39E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197994BDBM50197994((2S)-methyl 2-(4-(3-(3,5-dichlorophenyl)-1-(naphth...)
Affinity DataIC50: 2.84E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197986BDBM50197986((S)-methyl 2-(3-(3-(3,5-dichlorophenyl)-1-(naphtha...)
Affinity DataIC50: 4.74E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197997BDBM50197997(4-(1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,5-dichl...)
Affinity DataIC50: 6.48E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197987BDBM50197987((S)-methyl 2-(4-(3-(3,5-dichlorophenyl)-1-(naphtha...)
Affinity DataIC50: 7.60E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50197990BDBM50197990(4-(3-(3,5-dichlorophenyl)-1-(naphthalen-2-yl)-1H-p...)
Affinity DataIC50: 9.33E+3nMAssay Description:Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed