Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50022636
TargetAurora kinase B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to Aurora B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to Aurora A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Aurora B in human SW620 cells assessed as inhibition of histone H3 phosphorylation at Ser10 residue incubated for 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase C(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataKi:  17nMAssay Description:Binding affinity to Aurora C (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 27nMAssay Description:Inhibition of Aurora A (unknown origin) using LRRWSLGL as substrate in presence of ATP traced with gamma 33-ATP by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase C(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 120nMAssay Description:Inhibition of Aurora C (unknown origin) using peptide auroratide as substrate in presence of ATP traced with gamma 33-ATP by Scintillation Proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 135nMAssay Description:Inhibition of Aurora B (unknown origin) using peptide auroratide as substrate in presence of ATP traced with gamma 33-ATP by Scintillation Proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed