Compile Data Set for Download or QSAR
maximum 50k data
Found 43 Enz. Inhib. hit(s) with all data for entry = 2251
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  0.200nM ΔG°:  -51.5kJ/mole IC50:  0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/mole IC50:  1.10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/mole IC50:  0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  1.10nM ΔG°:  -47.5kJ/mole IC50:  0.200nM EC50:  0.100nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18632((18Z)-18-{[3-(1-hydroxyethyl)thiophen-2-yl]methyli...)
Affinity DataKi:  1.20nM ΔG°:  -47.3kJ/mole IC50:  1.60nM EC50:  1.30nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18628((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(2,2,2-tri...)
Affinity DataKi:  1.40nM ΔG°:  -47.0kJ/mole IC50:  0.400nM EC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  2.10nM ΔG°:  -46.0kJ/mole IC50:  1.40nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  4.40nM ΔG°:  -44.3kJ/mole IC50:  6.10nM EC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  7.20nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  10nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  21nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  38nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  42nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  48nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  57nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  110nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  150nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  190nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  290nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  290nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  346nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18632((18Z)-18-{[3-(1-hydroxyethyl)thiophen-2-yl]methyli...)
Affinity DataKi:  410nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18628((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(2,2,2-tri...)
Affinity DataKi:  670nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  790nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  980nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  1.40E+3nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18632((18Z)-18-{[3-(1-hydroxyethyl)thiophen-2-yl]methyli...)
Affinity DataKi:  1.53E+3nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18628((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(2,2,2-tri...)
Affinity DataKi:  1.78E+3nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18628((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(2,2,2-tri...)
Affinity DataKi:  1.90E+3nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18632((18Z)-18-{[3-(1-hydroxyethyl)thiophen-2-yl]methyli...)
Affinity DataKi:  2.29E+3nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18629((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(1S)-2,2,...)
Affinity DataIC50:  0.200nM EC50:  0.200nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18621(1-(2-{[(18Z)-13-hydroxy-12-methoxy-3,5,5-trimethyl...)
Affinity DataIC50:  0.300nM EC50:  0.600nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18624((18Z)-18-({3-[(1E)-1-(ethoxyimino)ethyl]thiophen-2...)
Affinity DataIC50:  0.5nM EC50:  1.90nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18624((18Z)-18-({3-[(1E)-1-(ethoxyimino)ethyl]thiophen-2...)
Affinity DataIC50:  0.5nM EC50:  0.400nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18630((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(1R)-2,2,...)
Affinity DataIC50:  0.600nM EC50:  1.40nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18620(2-{[(18Z)-13-hydroxy-12-methoxy-3,5,5-trimethyl-17...)
Affinity DataIC50:  0.800nM EC50:  0.200nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18633((18Z)-18-{[3-(1-hydroxypentyl)thiophen-2-yl]methyl...)
Affinity DataIC50:  0.900nM EC50:  0.600nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18619((18Z)-12-methoxy-3,5,5-trimethyl-18-[(3-{[(2,2,2-t...)
Affinity DataIC50:  0.900nM EC50:  0.5nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18615((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(piperidin...)
Affinity DataIC50:  1nM EC50:  0.300nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18631((18Z)-18-[(3-cyclohexanecarbonylthiophen-2-yl)meth...)
Affinity DataIC50:  1nM EC50:  0.400nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18618((18Z)-18-({3-[(2-hydroxyethoxy)methyl]thiophen-2-y...)
Affinity DataIC50:  1nM EC50:  1.60nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18625(Ester, 27 | methyl 2-{[(18Z)-13-hydroxy-12-methoxy...)
Affinity DataIC50:  1.80nM EC50:  1.40nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataEC50:  0.600nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair