Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50021117
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162828(1-(1-(3-(3-(3,4-dichlorophenyl)-5-(methylsulfonyl)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50152989(Carbamic acid 2-[5-carbamoyl-3-(4-iodo-phenyl)-4,5...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50182092(4-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221229(3-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221228(1-(4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221221(ethyl 3-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221219(1-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221238(1-(4-(5-methoxy-1H-indol-3-yl)piperidin-1-yl)-3-(5...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221241(1-(4-(6-chloro-1H-indol-3-yl)piperidin-1-yl)-3-(5-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221230(1-(4-(1H-pyrrolo[2,3-c]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221225(1-(4-(7-chloro-1H-indol-3-yl)piperidin-1-yl)-3-(5-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221223(1-(4-(5-chloro-2-methyl-1H-indol-3-yl)piperidin-1-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221227(N-ethyl-6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221230(1-(4-(1H-pyrrolo[2,3-c]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 38nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221214(6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluo...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221240(1-(4-(5-chloro-1H-indol-3-yl)piperidin-1-yl)-3-(5-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221233(N-(2-aminoethyl)-6-fluoro-3-(1-(3-(5-(methylsulfon...)
Affinity DataIC50: 47nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221222(1-(3-(4-bromophenyl)-5-(methylsulfonyl)-4,5,6,7-te...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221228(1-(4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221218(1-(4-(5-methyl-1H-indol-3-yl)piperidin-1-yl)-3-(5-...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221236(1-(1-(3-(4-(1H-indol-3-yl)piperidin-1-yl)-2-hydrox...)
Affinity DataIC50: 72nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221220(1-(4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221216(1-(4-(1H-pyrrolo[3,2-b]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 95nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221217(1-(1-(3-(4-(5-chloro-1H-indol-3-yl)piperidin-1-yl)...)
Affinity DataIC50: 95nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221226(6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluo...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221216(1-(4-(1H-pyrrolo[3,2-b]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221242(methyl 6-fluoro-3-(1-(2-hydroxy-3-(5-(methylsulfon...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221231(methyl 6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221237(methyl 3-(1-(3-(5-acetyl-3-(4-(trifluoromethyl)phe...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221220(1-(4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 150nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221234(1-(4-(6-fluorobenzo[b]thiophen-3-yl)piperidin-1-yl...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221213(1-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221215(1-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221239(methyl 3-(1-(3-(5-acetyl-3-(4-(trifluoromethyl)phe...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221215(1-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221224(1-(1-(3-(4-(6-fluorobenzo[b]thiophen-3-yl)piperidi...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221214(6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluo...)
Affinity DataIC50: 340nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221232(1-(1-(3-(4-(6-fluorobenzofuran-3-yl)piperidin-1-yl...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221235(6-fluoro-N,N-dimethyl-3-(1-(3-(5-(methylsulfonyl)-...)
Affinity DataIC50: 370nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221221(ethyl 3-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(...)
Affinity DataIC50: 410nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162828(1-(1-(3-(3-(3,4-dichlorophenyl)-5-(methylsulfonyl)...)
Affinity DataIC50: 800nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50182092(4-(1-(2-hydroxy-3-(5-(methylsulfonyl)-3-(4-(triflu...)
Affinity DataIC50: 800nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50152989(Carbamic acid 2-[5-carbamoyl-3-(4-iodo-phenyl)-4,5...)
Affinity DataIC50: 800nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221219(1-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl...)
Affinity DataIC50: 860nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221227(N-ethyl-6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221231(methyl 6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221233(N-(2-aminoethyl)-6-fluoro-3-(1-(3-(5-(methylsulfon...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50221226(6-fluoro-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin S in human JY cells by invariant chain degradation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed