Compile Data Set for Download or QSAR
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Found 45 Enz. Inhib. hit(s) with all data for entry = 50021650
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  380nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  640nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226455(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3,6-dimeth...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226455(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3,6-dimeth...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226447(2-amino-3,6-dimethyl-6-phenyl-5,6-dihydro-3H-pyrim...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226440(2-amino-6-(3,4-dichlorophenyl)-3,6-dimethyl-5,6-di...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226443(6-(2-(1H-indol-6-yl)ethyl)-2-amino-3-methylpyrimid...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226457(6-(3-(pyridin-3-yl)phenethyl)-2-amino-3-methylpyri...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226441(2-amino-3-methyl-6-(2-(naphthalen-2-yl)ethyl)pyrim...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226441(2-amino-3-methyl-6-(2-(naphthalen-2-yl)ethyl)pyrim...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226449(2-amino-6-[2-(1,1'-biphenyl-3-yl)ethyl]-3-methylpy...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226456(2-amino-3,6-dimethyl-6-phenethyl-5,6-dihydropyrimi...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226450((S)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226441(2-amino-3-methyl-6-(2-(naphthalen-2-yl)ethyl)pyrim...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226443(6-(2-(1H-indol-6-yl)ethyl)-2-amino-3-methylpyrimid...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226444(6-(3-(1H-pyrrol-2-yl)phenethyl)-2-amino-3-methylpy...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226443(6-(2-(1H-indol-6-yl)ethyl)-2-amino-3-methylpyrimid...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226458(2-amino-6-(3,4-dichlorophenyl)-6-methyl-5,6-dihydr...)
Affinity DataIC50:  7.90E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226458(2-amino-6-(3,4-dichlorophenyl)-6-methyl-5,6-dihydr...)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226445(2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226453(2-amino-6-[2-(3'-methoxy-1,1'-biphenyl-3-yl)ethyl]...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226444(6-(3-(1H-pyrrol-2-yl)phenethyl)-2-amino-3-methylpy...)
Affinity DataIC50:  9.90E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226444(6-(3-(1H-pyrrol-2-yl)phenethyl)-2-amino-3-methylpy...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226445(2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226452(2-amino-6-methyl-6-phenyl-5,6-dihydropyrimidin-4(3...)
Affinity DataIC50:  1.40E+5nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226457(6-(3-(pyridin-3-yl)phenethyl)-2-amino-3-methylpyri...)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226452(2-amino-6-methyl-6-phenyl-5,6-dihydropyrimidin-4(3...)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50:  2.20E+5nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226451(2-amino-6-(3,4-dichlorophenyl)-5,6-dihydropyrimidi...)
Affinity DataIC50:  4.80E+5nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed