Compile Data Set for Download or QSAR
maximum 50k data
Found 41 Enz. Inhib. hit(s) with all data for entry = 2969
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26467(3-({4-[methyl(3-methyl-1H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26477(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylph...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26478(6,7-dimethoxy-N-(3-methyl-1H-indazol-6-yl)quinazol...)
Affinity DataIC50:  1.70nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  2.60nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26469(3-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  5.60nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26479(4-N-(3-methyl-1H-indazol-6-yl)-2-N-(3,4,5-trimetho...)
Affinity DataIC50:  6.30nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26476(5-({2-[(3-bromophenyl)amino]pyrimidin-4-yl}amino)-...)
Affinity DataIC50:  6.30nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26471(3-({4-[methyl(2-methyl-2H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  7.60nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26473(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-5-yl)(meth...)
Affinity DataIC50:  17nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  30nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26468(3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  36nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26472(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-6-yl)(meth...)
Affinity DataIC50:  63nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM26475(2-N,4-N-bis(3-bromophenyl)-5-fluoropyrimidine-2,4-...)
Affinity DataIC50:  400nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  500nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gsk

LigandPNGBDBM26467(3-({4-[methyl(3-methyl-1H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  700nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gsk

LigandPNGBDBM26468(3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gsk

LigandPNGBDBM26469(3-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gsk

LigandPNGBDBM26472(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-6-yl)(meth...)
Affinity DataIC50:  1.70E+3nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gsk

LigandPNGBDBM26468(3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  1.70E+3nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gsk

LigandPNGBDBM26471(3-({4-[methyl(2-methyl-2H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  2.90E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gsk

LigandPNGBDBM26471(3-({4-[methyl(2-methyl-2H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  3.90E+3nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gsk

LigandPNGBDBM26467(3-({4-[methyl(3-methyl-1H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  4.80E+3nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gsk

LigandPNGBDBM26468(3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  6.30E+3nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gsk

LigandPNGBDBM26467(3-({4-[methyl(3-methyl-1H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  7.20E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gsk

LigandPNGBDBM26473(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-5-yl)(meth...)
Affinity DataIC50:  9.00E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gsk

LigandPNGBDBM26471(3-({4-[methyl(2-methyl-2H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  9.20E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gsk

LigandPNGBDBM26468(3-({4-[(1,3-dimethyl-1H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  9.30E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gsk

LigandPNGBDBM26472(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-6-yl)(meth...)
Affinity DataIC50:  1.50E+4nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gsk

LigandPNGBDBM26469(3-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  1.60E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gsk

LigandPNGBDBM26467(3-({4-[methyl(3-methyl-1H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  1.60E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gsk

LigandPNGBDBM26471(3-({4-[methyl(2-methyl-2H-indazol-6-yl)amino]pyrim...)
Affinity DataIC50:  1.80E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gsk

LigandPNGBDBM26469(3-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  2.00E+4nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gsk

LigandPNGBDBM26472(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-6-yl)(meth...)
Affinity DataIC50:  2.50E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gsk

LigandPNGBDBM26472(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-6-yl)(meth...)
Affinity DataIC50:  2.60E+4nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gsk

LigandPNGBDBM26469(3-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  3.10E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gsk

LigandPNGBDBM26473(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-5-yl)(meth...)
Affinity DataIC50:  3.30E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gsk

LigandPNGBDBM26473(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-5-yl)(meth...)
Affinity DataIC50:  3.30E+4nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gsk

LigandPNGBDBM26473(3-({4-[(1,2-dimethyl-1H-1,3-benzodiazol-5-yl)(meth...)
Affinity DataIC50:  4.50E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  6.60E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gsk

LigandPNGBDBM26470(3-({4-[(2-benzyl-3-methyl-2H-indazol-6-yl)(methyl)...)
Affinity DataIC50:  7.90E+4nMAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed