Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50027016
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264895BDBM50264895(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-2...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed as reversal of N-alpha-methylhistamine-induced inhibition of fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264895BDBM50264895(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-2...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264934BDBM50264934(5-fluoro-2-(pyridin-2-yl)-1-(4-(3-(pyrrolidin-1-yl...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265014BDBM50265014(1-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Mouse)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264895BDBM50264895(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-2...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to mouse histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264932BDBM50264932(1-(4-(3-(4-benzylpiperidin-1-yl)propoxy)phenyl)-5-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265094BDBM50265094(2-(ethylthio)-5-fluoro-1-(4-(3-(piperidin-1-yl)pro...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264897BDBM50264897(4-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264977BDBM50264977(5-fluoro-1-(4-(3-(4-methyl-1,4-diazepan-1-yl)propo...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264974BDBM50264974((S)-5-fluoro-1-(4-(3-(3-isopropylpyrrolidin-1-yl)p...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264935BDBM50264935(1-(4-(3-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)propo...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264976BDBM50264976(1-(4-(3-(azepan-1-yl)propoxy)phenyl)-5-fluoro-2-(p...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265093BDBM50265093(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-1...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265052BDBM50265052(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-1...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265050BDBM50265050(1-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264896BDBM50264896(1-(4-(3-(3,5-dimethylpiperidin-1-yl)propoxy)phenyl...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264933BDBM50264933(5-fluoro-1-(4-(3-(4-methylpiperazin-1-yl)propoxy)p...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265095BDBM50265095(2-ethoxy-5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265014BDBM50265014(1-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  16nMAssay Description:Binding affinity to human ERG assessed as rubidium efflux at 5 ug/mL pre-equilibrated for 30 mins by DiBAC4(3)-based flame atomic absorbance spectros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265015BDBM50265015(methyl 1-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265049BDBM50265049(1-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264975BDBM50264975(3-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264974BDBM50264974((S)-5-fluoro-1-(4-(3-(3-isopropylpyrrolidin-1-yl)p...)
Affinity DataKi:  26nMAssay Description:Binding affinity to human ERG assessed as rubidium efflux at 5 ug/mL pre-equilibrated for 30 mins by DiBAC4(3)-based flame atomic absorbance spectros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264975BDBM50264975(3-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  42nMAssay Description:Binding affinity to human ERG assessed as rubidium efflux at 5 ug/mL pre-equilibrated for 30 mins by DiBAC4(3)-based flame atomic absorbance spectros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265015BDBM50265015(methyl 1-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo...)
Affinity DataKi:  49nMAssay Description:Binding affinity to human ERG assessed as rubidium efflux at 5 ug/mL pre-equilibrated for 30 mins by DiBAC4(3)-based flame atomic absorbance spectros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264897BDBM50264897(4-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  62nMAssay Description:Binding affinity to human ERG assessed as rubidium efflux at 5 ug/mL pre-equilibrated for 30 mins by DiBAC4(3)-based flame atomic absorbance spectros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264895BDBM50264895(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-2...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human ERG assessed as rubidium efflux at 5 ug/mL pre-equilibrated for 30 mins by DiBAC4(3)-based flame atomic absorbance spectros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265012BDBM50265012(2-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  94nMAssay Description:Binding affinity to human ERG assessed as rubidium efflux at 5 ug/mL pre-equilibrated for 30 mins by DiBAC4(3)-based flame atomic absorbance spectros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265051BDBM50265051(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazo...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265012BDBM50265012(2-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  107nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265013BDBM50265013(2-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imid...)
Affinity DataKi:  713nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed