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Target
Histamine H3 receptor
Ligand
BDBM50264895
Substrate
n/a
Meas. Tech.
ChEMBL_496463 (CHEMBL1004594)
Ki
1.8±n/a nM
Citation
 Aslanian, R; Zhu, X; Vaccaro, HA; Shih, NY; Piwinski, JJ; Williams, SM; West, RE Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands. Bioorg Med Chem Lett 18:5032-6 (2008) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_MOUSE | Hrh3
Type:
PROTEIN
Mol. Mass.:
48560.37
Organism:
Mus musculus
Description:
ChEMBL_988451
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50264895
Synonyms:
5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-2-(pyridin-2-yl)-1H-benzo[d]imidazole | CHEMBL495698
Type:
Small organic molecule
Emp. Form.:
C26H27FN4O
Mol. Mass.:
430.5172
SMILES:
Fc1ccc2n(c(nc2c1)-c1ccccn1)-c1ccc(OCCCN2CCCCC2)cc1
Structure:
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