Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50027410
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245983BDBM50245983((2R,3S,4S)-N-(3,5-dichlorophenyl)-2-ethyl-3-methyl...)
Affinity DataKi:  70nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245937BDBM50245937((2R,3S,4S)-N-(3-bromophenyl)-2-ethyl-3-methyl-4-(p...)
Affinity DataKi:  100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246518BDBM50246518(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataKi:  100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245772BDBM50245772((4-bromophenyl)((2R,3S,4S)-2-ethyl-3-methyl-4-(phe...)
Affinity DataKi:  100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245982BDBM50245982((2R,3S,4S)-N-(3,5-dimethoxyphenyl)-2-ethyl-3-methy...)
Affinity DataKi:  200nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245835BDBM50245835((2R,3S,4S)-N-(3-chlorophenyl)-2-ethyl-3-methyl-4-(...)
Affinity DataKi:  300nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245934BDBM50245934((2R,3S,4S)-N-(4-chlorophenyl)-2-ethyl-3-methyl-4-(...)
Affinity DataKi:  300nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246516BDBM50246516(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataKi:  400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246517BDBM50246517((4-chlorophenyl)((2R,3S,4S)-2-ethyl-3-methyl-4-(ph...)
Affinity DataKi:  400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245981BDBM50245981((2R,3S,4S)-2-ethyl-3-methyl-N-phenyl-4-(phenylamin...)
Affinity DataKi:  400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245935BDBM50245935((2R,3S,4S)-2-ethyl-N-(3-methoxyphenyl)-3-methyl-4-...)
Affinity DataKi:  500nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246468BDBM50246468(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataKi:  500nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245983BDBM50245983((2R,3S,4S)-N-(3,5-dichlorophenyl)-2-ethyl-3-methyl...)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245982BDBM50245982((2R,3S,4S)-N-(3,5-dimethoxyphenyl)-2-ethyl-3-methy...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246516BDBM50246516(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245984BDBM50245984(cis-(2(R)-ethyl-4-(phenylamino)-3,4-dihydroquinoli...)
Affinity DataKi:  800nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245772BDBM50245772((4-bromophenyl)((2R,3S,4S)-2-ethyl-3-methyl-4-(phe...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245937BDBM50245937((2R,3S,4S)-N-(3-bromophenyl)-2-ethyl-3-methyl-4-(p...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245835BDBM50245835((2R,3S,4S)-N-(3-chlorophenyl)-2-ethyl-3-methyl-4-(...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246518BDBM50246518(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246517BDBM50246517((4-chlorophenyl)((2R,3S,4S)-2-ethyl-3-methyl-4-(ph...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245981BDBM50245981((2R,3S,4S)-2-ethyl-3-methyl-N-phenyl-4-(phenylamin...)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245935BDBM50245935((2R,3S,4S)-2-ethyl-N-(3-methoxyphenyl)-3-methyl-4-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246468BDBM50246468(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245934BDBM50245934((2R,3S,4S)-N-(4-chlorophenyl)-2-ethyl-3-methyl-4-(...)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245984BDBM50245984(cis-(2(R)-ethyl-4-(phenylamino)-3,4-dihydroquinoli...)
Affinity DataIC50: 3.20E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245936BDBM50245936((2R,3S,4S)-2-ethyl-N-(4-methoxyphenyl)-3-methyl-4-...)
Affinity DataIC50: 6.00E+3nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246030BDBM50246030((4-methoxyphenyl)((3R,4S)-3-methyl-4-(phenylamino)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246032BDBM50246032((2S,3R,4R)-N-(3,5-dichlorophenyl)-2-ethyl-3-methyl...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245774BDBM50245774(((2R,3R,4S)-2-ethyl-3-methyl-4-(methyl(phenyl)amin...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246515BDBM50246515(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245775BDBM50245775((2R,3S,4S)-N-(2-chlorophenyl)-2-ethyl-3-methyl-4-(...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245773BDBM50245773(((2R,3S,4S)-2-ethyl-3-methyl-4-(phenylamino)-3,4-d...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246031BDBM50246031((S)-(4-methoxyphenyl)(4-(phenylamino)-3,4-dihydroq...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246029BDBM50246029(trans-((2(R)-ethyl-4-(phenylamino)-3,4-dihydroquin...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human P2Y1 receptor in HEK293 cells assessed as intracellular calcium level by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed