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Found 11 Enz. Inhib. hit(s) with all data for entry = 50027562
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216551(3-pentyl-1H-pyrazole-5-carboxylic acid | 5-butylpy...)
Affinity DataKi:  72nMAssay Description:Binding affinity at GPR109aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132140(1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic...)
Affinity DataKi:  156nMAssay Description:Binding affinity at GPR109aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132142(4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acid |...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity at GPR109aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataIC50:  500nMAssay Description:Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataIC50:  500nMAssay Description:Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataIC50:  3.00E+3nMAssay Description:Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208122((+)-5-(5-chloro-thiophen-3-yl)-5-methyl-4-oxo-4,5-...)
Affinity DataEC50:  200nMAssay Description:Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241028(1-Isopropyl-1H-benzotriazole-5-carboxylic acid | 1...)
Affinity DataEC50:  400nMAssay Description:Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208122((+)-5-(5-chloro-thiophen-3-yl)-5-methyl-4-oxo-4,5-...)
Affinity DataEC50:  1.72E+3nMAssay Description:Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208137((+)-5-(5-bromo-thiophen-3-yl)-5-methyl-4-oxo-4,5-d...)
Affinity DataEC50:  1.47E+3nMAssay Description:Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208137((+)-5-(5-bromo-thiophen-3-yl)-5-methyl-4-oxo-4,5-d...)
Affinity DataEC50:  110nMAssay Description:Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed