Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50027565
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246447BDBM50246447(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246298BDBM50246298(N-(2-hydroxyethyl)-4-(4-(1-isopropyl-2-methyl-1H-i...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246301BDBM50246301(4-(4-(1-cyclopentyl-2-methyl-1H-imidazol-5-yl)pyri...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246350BDBM50246350(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246349BDBM50246349(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246255BDBM50246255(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246254BDBM50246254(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246397BDBM50246397(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246256BDBM50246256(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246448BDBM50246448(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246297BDBM50246297(N-cyclopropyl-4-(4-(1-isopropyl-2-methyl-1H-imidaz...)
Affinity DataIC50: 17nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246300BDBM50246300(4-(4-(1-(cyclopropylmethyl)-2-methyl-1H-imidazol-5...)
Affinity DataIC50: 42nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246299BDBM50246299(4-(4-(1-ethyl-2-methyl-1H-imidazol-5-yl)pyrimidin-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase-like 1 [2-358](Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246347BDBM50246347(4-(4-(1-isopropyl-2-(methoxymethyl)-1H-imidazol-5-...)
Affinity DataIC50: 62nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246346BDBM50246346(4-(4-(2-cyclopropyl-1-isopropyl-1H-imidazol-5-yl)p...)
Affinity DataIC50: 81nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246397BDBM50246397(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246253BDBM50246253(AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246447BDBM50246447(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246297BDBM50246297(N-cyclopropyl-4-(4-(1-isopropyl-2-methyl-1H-imidaz...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246395BDBM50246395(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Zap70More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246350BDBM50246350(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246349BDBM50246349(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246396BDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246254BDBM50246254(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246256BDBM50246256(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246399BDBM50246399(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246348BDBM50246348(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246398BDBM50246398(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246255BDBM50246255(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246298BDBM50246298(N-(2-hydroxyethyl)-4-(4-(1-isopropyl-2-methyl-1H-i...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246448BDBM50246448(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed