Compile Data Set for Download or QSAR
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Found 66 Enz. Inhib. hit(s) with all data for entry = 3292
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30504(5,6-Dihydro-1H-pyridin-2-one, 4d)
Affinity DataIC50: <10nM EC50:  23nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30508(5,6-Dihydro-1H-pyridin-2-one, 4h)
Affinity DataIC50: <10nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30516(5,6-Dihydro-1H-pyridin-2-one, 4p)
Affinity DataIC50: <10nM EC50:  60nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30530(5,6-Dihydro-1H-pyridin-2-one, 4ad)
Affinity DataIC50: <10nM EC50:  16nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30418(BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...)
Affinity DataIC50: <10nM EC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30452(Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...)
Affinity DataIC50: <10nM EC50:  34nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30537(5,6-Dihydro-1H-pyridin-2-one, 4ai)
Affinity DataIC50: <10nM EC50:  32nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30538(5,6-Dihydro-1H-pyridin-2-one, 4aj)
Affinity DataIC50: <10nM EC50:  9nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30541(5,6-Dihydro-1H-pyridin-2-one, 4am)
Affinity DataIC50: <10nM EC50:  160nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30542(5,6-Dihydro-1H-pyridin-2-one, 4an)
Affinity DataIC50: <10nM EC50:  34nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30543(5,6-Dihydro-1H-pyridin-2-one, 4ao)
Affinity DataIC50: <10nM EC50:  45nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30544(5,6-Dihydro-1H-pyridin-2-one, 4ap)
Affinity DataIC50: <10nM EC50:  55nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30523(5,6-Dihydro-1H-pyridin-2-one, 4w)
Affinity DataIC50:  20nM EC50:  170nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30505(5,6-Dihydro-1H-pyridin-2-one, 4e)
Affinity DataIC50:  22nM EC50:  150nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30452(Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...)
Affinity DataIC50: <25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30418(BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...)
Affinity DataIC50: <25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30538(5,6-Dihydro-1H-pyridin-2-one, 4aj)
Affinity DataIC50: <25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30516(5,6-Dihydro-1H-pyridin-2-one, 4p)
Affinity DataIC50: <25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30530(5,6-Dihydro-1H-pyridin-2-one, 4ad)
Affinity DataIC50: <25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30504(5,6-Dihydro-1H-pyridin-2-one, 4d)
Affinity DataIC50: <25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30508(5,6-Dihydro-1H-pyridin-2-one, 4h)
Affinity DataIC50: <25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30531(5,6-Dihydro-1H-pyridin-2-one, 4ae)
Affinity DataIC50:  26nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30534(5,6-Dihydro-1H-pyridin-2-one, 4af)
Affinity DataIC50:  27nM EC50:  120nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30544(5,6-Dihydro-1H-pyridin-2-one, 4ap)
Affinity DataIC50:  28nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30522(5,6-Dihydro-1H-pyridin-2-one, 4v)
Affinity DataIC50:  28nM EC50:  880nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30542(5,6-Dihydro-1H-pyridin-2-one, 4an)
Affinity DataIC50:  28nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30543(5,6-Dihydro-1H-pyridin-2-one, 4ao)
Affinity DataIC50:  29nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30531(5,6-Dihydro-1H-pyridin-2-one, 4ae)
Affinity DataIC50:  31nM EC50:  220nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30517(5,6-Dihydro-1H-pyridin-2-one, 4q)
Affinity DataIC50:  35nM EC50:  120nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30510(5,6-Dihydro-1H-pyridin-2-one, 4j)
Affinity DataIC50:  39nM EC50:  22nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30528(5,6-Dihydro-1H-pyridin-2-one, 4ab)
Affinity DataIC50:  40nM EC50:  39nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30506(5,6-Dihydro-1H-pyridin-2-one, 4f)
Affinity DataIC50:  42nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30535(5,6-Dihydro-1H-pyridin-2-one, 4ag)
Affinity DataIC50:  43nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30509(5,6-Dihydro-1H-pyridin-2-one, 4i)
Affinity DataIC50:  43nM EC50:  33nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30521(5,6-Dihydro-1H-pyridin-2-one, 4u)
Affinity DataIC50:  46nM EC50:  100nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30528(5,6-Dihydro-1H-pyridin-2-one, 4ab)
Affinity DataIC50:  47nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30535(5,6-Dihydro-1H-pyridin-2-one, 4ag)
Affinity DataIC50:  47nM EC50:  350nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30515(5,6-Dihydro-1H-pyridin-2-one, 4o)
Affinity DataIC50:  51nM EC50:  700nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30517(5,6-Dihydro-1H-pyridin-2-one, 4q)
Affinity DataIC50:  51nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30537(5,6-Dihydro-1H-pyridin-2-one, 4ai)
Affinity DataIC50:  51nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30506(5,6-Dihydro-1H-pyridin-2-one, 4f)
Affinity DataIC50:  57nM EC50:  74nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30534(5,6-Dihydro-1H-pyridin-2-one, 4af)
Affinity DataIC50:  63nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30509(5,6-Dihydro-1H-pyridin-2-one, 4i)
Affinity DataIC50:  66nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30510(5,6-Dihydro-1H-pyridin-2-one, 4j)
Affinity DataIC50:  73nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30541(5,6-Dihydro-1H-pyridin-2-one, 4am)
Affinity DataIC50:  74nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30521(5,6-Dihydro-1H-pyridin-2-one, 4u)
Affinity DataIC50:  99nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30525(5,6-Dihydro-1H-pyridin-2-one, 4y)
Affinity DataIC50:  120nM EC50:  3.10E+3nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30507(5,6-Dihydro-1H-pyridin-2-one, 4g)
Affinity DataIC50:  130nM EC50:  7.30E+3nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30523(5,6-Dihydro-1H-pyridin-2-one, 4w)
Affinity DataIC50:  130nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30525(5,6-Dihydro-1H-pyridin-2-one, 4y)
Affinity DataIC50:  190nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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