Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 3104
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28043BDBM28043(7-amino-4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-...)
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28037BDBM28037(4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-carboxyl...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28039BDBM28039(5-[4-(3-phenylphenyl)thieno[2,3-c]pyridin-2-yl]-1H...)
Affinity DataIC50: 80nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28042BDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28034BDBM28034(4-[(4-phenylphenyl)amino]thieno[2,3-c]pyridine-2-c...)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28044BDBM28044(7-amino-4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-...)
Affinity DataIC50: 160nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28036BDBM28036(N-(4-phenylphenyl)-2-(1H-1,2,3,4-tetrazol-5-yl)thi...)
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28035BDBM28035(4-[(4-phenylphenyl)amino]thieno[2,3-c]pyridine-2-c...)
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28040BDBM28040(4-(4-phenylphenoxy)thieno[2,3-c]pyridine-2-carboxy...)
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28045BDBM28045(CHEMBL523921 | 4-(4-iodophenoxy)thieno[2,3-c]pyrid...)
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28038BDBM28038(4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-carboxam...)
Affinity DataIC50: 2.90E+3nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28044BDBM28044(7-amino-4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-...)
Affinity DataIC50: 4.30E+3nMpH: 7.5 T: 2°CAssay Description:The ERK HTRF assays were carried out using biotin-MBP protein as a substrate. The reaction was carried out in black 96 half-well plates. At designate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 28044BDBM28044(7-amino-4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-...)
Affinity DataIC50: 1.30E+4nMpH: 7.5 T: 2°CAssay Description:MEK1 cascade HTRF assays were carried out using inactive Erk2 as a downstream kinase with biotin-MBP protein as the final substrate. The reaction was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Laboratories

LigandChemical structure of BindingDB Monomer ID 28041BDBM28041(4-(4-phenylphenoxy)thieno[2,3-c]pyridine-2-carboxa...)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2009
Entry Details Article
PubMed