Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50030282
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293643(N-cyclopentyl-6-(2-phenylethynyl)nicotinamide | CH...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293655((6-(2-phenylethynyl)pyridin-3-yl)(thiomorpholino)m...)
Affinity DataEC50:  46nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293651((4-methylpiperidin-1-yl)(6-(2-phenylethynyl)pyridi...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293648(6-(phenylethynyl)-N-(thiophen-3-ylmethyl)nicotinam...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293646(N-(furan-2-ylmethyl)-6-(phenylethynyl)nicotinamide...)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293644(N-cyclohexyl-6-(2-phenylethynyl)nicotinamide | CHE...)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293649((6-(2-phenylethynyl)pyridin-3-yl)(piperidin-1-yl)m...)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293642(N-isopentyl-6-(2-phenylethynyl)nicotinamide | CHEM...)
Affinity DataEC50:  510nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293650((4-methylpiperidin-1-yl)(4-(2-phenylethynyl)phenyl...)
Affinity DataEC50:  720nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293656(4-(morpholino(4-(2-phenylethynyl)phenyl)methyl)mor...)
Affinity DataEC50:  970nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293654(morpholino(6-(2-phenylethynyl)pyridin-3-yl)methano...)
Affinity DataEC50:  990nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293647(4-(phenylethynyl)-N-(thiophen-3-ylmethyl)benzamide...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293645(N-(4-methylcyclohexyl)-6-(2-phenylethynyl)nicotina...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293653((4-methylpiperazin-1-yl)(6-(2-phenylethynyl)pyridi...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293643(N-cyclopentyl-6-(2-phenylethynyl)nicotinamide | CH...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [3H]MPEP from human recombinant mGluR5 expressed in BHK cells at by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293652((4-methylpiperazin-1-yl)(4-(2-phenylethynyl)phenyl...)
Affinity DataEC50:  3.10E+3nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50293641(6-Phenylethynyl-nicotinamide | CHEMBL561554)
Affinity DataEC50:  6.60E+3nMAssay Description:Agonist activity at human mGluR5 transiently transfected in BHK cells assessed as potentiation of L-glutamate-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed