Compile Data Set for Download or QSAR
maximum 50k data
Found 33 Enz. Inhib. hit(s) with all data for entry = 50030638
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299469(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-2-(3,4-d...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299469(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-2-(3,4-d...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299469(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-2-(3,4-d...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299470(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-N-(2-chl...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299470(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-N-(2-chl...)
Affinity DataKi:  10.4nMAssay Description:Displacement of [3H]osanetant from human recombinant NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299470(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-N-(2-chl...)
Affinity DataKi:  11.9nMAssay Description:Displacement of [3H]osanetant from guinea pig recombinant NK3 receptor A1142.58T expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  35.5nMAssay Description:Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299470(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-N-(2-chl...)
Affinity DataKi:  70.9nMAssay Description:Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  109nMAssay Description:Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299469(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-2-(3,4-d...)
Affinity DataKi:  152nMAssay Description:Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299468(2-(3,4-dichlorophenyl)-N-(4-fluoro-3-trifluorometh...)
Affinity DataKi:  182nMAssay Description:Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299469(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-2-(3,4-d...)
Affinity DataKi:  515nMAssay Description:Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299470(4-[4-(acetylmethyl-amino)-piperidin-1-yl]-N-(2-chl...)
Affinity DataKi:  953nMAssay Description:Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity to human NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at guinea pig NK3 receptor expressed in cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKd:  0.0800nMAssay Description:Apparent binding affinity to guinea pig NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKd:  0.150nMAssay Description:Equilibrium binding affinity to guinea pig NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human NK3 receptor expressed in cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKd:  0.200nMAssay Description:Equilibrium binding affinity to human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKd:  0.220nMAssay Description:Apparent binding affinity to human NK3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed