Compile Data Set for Download or QSAR
maximum 50k data
Found 47 Enz. Inhib. hit(s) with all data for entry = 50038940
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060685(9-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299661(9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081969(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060688(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081968(6-(4-Benzyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299665(7-hydroxy-4-(4-((3H-imidazol-4-yl)methyl)piperazin...)
Affinity DataKi:  2.25nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081970(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299662(7-fluoro-4-(4-((1H-imidazol-2-yl)methyl)piperazin-...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50258292(2-(4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pipera...)
Affinity DataKi:  11.7nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299664(9-methyl-4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin...)
Affinity DataKi:  17.8nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299663(7-fluoro-4-(4-(2-(1H-imidazol-1-yl)ethyl)piperazin...)
Affinity DataKi:  22.2nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299667(7-fluoro-4-(4-((4,5-dihydro-1H-imidazol-2-yl)methy...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299668((4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazi...)
Affinity DataKi:  44.3nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299666(7-fluoro-4-(4-(2-(1H-imidazol-4-yl)ethyl)piperazin...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  1.58E+3nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299661(9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi:  9.81E+3nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299662(7-fluoro-4-(4-((1H-imidazol-2-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299662(7-fluoro-4-(4-((1H-imidazol-2-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299662(7-fluoro-4-(4-((1H-imidazol-2-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299662(7-fluoro-4-(4-((1H-imidazol-2-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299662(7-fluoro-4-(4-((1H-imidazol-2-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299661(9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299661(9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299661(9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299661(9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081981(4-(4-Benzyl-piperazin-1-yl)-9-methyl-pyrrolo[1,2-a...)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081974(4-(4-Benzyl-piperazin-1-yl)-7-fluoro-pyrrolo[1,2-a...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299660(7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50258292(2-(4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pipera...)
Affinity DataIC50:  1.88E+3nMAssay Description:Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50299665(7-hydroxy-4-(4-((3H-imidazol-4-yl)methyl)piperazin...)
Affinity DataIC50:  2.63E+3nMAssay Description:Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060685(9-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataKd:  64.6nMAssay Description:Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081969(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataKd:  955nMAssay Description:Antagonist activity at 5HT3 receptor in spontaneously beating guinea pig right atrium assessed as inhibition of serotonin-induced maximum response by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060688(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at 5HT3 receptor in voltage-stimulated guinea pig left atrium assessed as positive inotropic potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(GUINEA PIG)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081970(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Affinity DataEC50:  340nMAssay Description:Intrinsic activity at 5HT3 receptor in voltage-stimulated guinea pig left atrium assessed as positive inotropic potency relative to serotoninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed