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Found 26 Enz. Inhib. hit(s) with all data for entry = 50031029
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300081(1-(2-fluoroethyl)-3-(4-(4-morpholino-1-(2,2,2-trif...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300085(1-methyl-3-(4-(4-morpholino-1-(2,2,2-trifluoroethy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305547(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305548(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305554(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305555(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305546(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305552(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305551(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305553(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305549(3-(4-(3,6-dihydro-2H-pyran-4-yl)-1-phenyl-1H-pyraz...)
Affinity DataIC50:  18nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305555(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  27nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305553(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  28nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305554(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305549(3-(4-(3,6-dihydro-2H-pyran-4-yl)-1-phenyl-1H-pyraz...)
Affinity DataIC50:  59nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305548(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50:  66nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300085(1-methyl-3-(4-(4-morpholino-1-(2,2,2-trifluoroethy...)
Affinity DataIC50:  194nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305546(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300081(1-(2-fluoroethyl)-3-(4-(4-morpholino-1-(2,2,2-trif...)
Affinity DataIC50:  315nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305550(3-(1-phenyl-4-(tetrahydro-2H-pyran-4-yl)-1H-pyrazo...)
Affinity DataIC50:  500nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305550(3-(1-phenyl-4-(tetrahydro-2H-pyran-4-yl)-1H-pyrazo...)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305551(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305552(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]py...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305547(1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)-1-(2,2,2-trifl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed