Compile Data Set for Download or QSAR
maximum 50k data
Found 12 Enz. Inhib. hit(s) with all data for entry = 50004408
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50:  2.24E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109110((S)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50:  3.27E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50:  3.42E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50:  3.78E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  5.30E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  8.25E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109110((S)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109110((S)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarba...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  2.15E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed