Compile Data Set for Download or QSAR
maximum 50k data
Found 36 Enz. Inhib. hit(s) with all data for entry = 50032190
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325724((R)-1-phenyl-N-((6-(trifluoromethoxy)-4'-(trifluor...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325741((S)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325726((R)-N-(2-chlorobenzyl)-1-(3-methoxyphenyl)ethanami...)
Affinity DataEC50:  3.70E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325727((R)-N-((2'-chlorobiphenyl-3-yl)methyl)-1-(3-methox...)
Affinity DataEC50:  350nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325728((R)-N-(4-methoxybenzyl)-1-(3-methoxyphenyl)ethanam...)
Affinity DataEC50:  370nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325729((R)-N-((2'-fluorobiphenyl-3-yl)methyl)-1-(3-methox...)
Affinity DataEC50:  2.70E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325730((R)-1-(3-methoxyphenyl)-N-((2'-methylbiphenyl-3-yl...)
Affinity DataEC50:  2.20E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325731((R)-N-((2'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Affinity DataEC50:  1.40E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325732((R)-N-((4'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Affinity DataEC50:  870nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325733((R)-1-(3-methoxyphenyl)-N-((4'-(trifluoromethyl)bi...)
Affinity DataEC50:  620nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325734((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50:  23nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325735((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50:  27nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325736((R)-1-(3-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Affinity DataEC50:  37nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325737(CHEMBL1224343 | N-((6-methoxy-4'-(trifluoromethyl)...)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325738((R)-N-((6-chloro-4'-(trifluoromethyl)biphenyl-3-yl...)
Affinity DataEC50:  280nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325739((R)-1-(4-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Affinity DataEC50:  58nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325740((R)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Affinity DataEC50:  17nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325741((S)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Affinity DataEC50:  3.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325724((R)-1-phenyl-N-((6-(trifluoromethoxy)-4'-(trifluor...)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325727((R)-N-((2'-chlorobiphenyl-3-yl)methyl)-1-(3-methox...)
Affinity DataEC50:  1.70E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325740((R)-1-(6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl...)
Affinity DataEC50:  2.10E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325739((R)-1-(4-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Affinity DataEC50:  1.70E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325737(CHEMBL1224343 | N-((6-methoxy-4'-(trifluoromethyl)...)
Affinity DataEC50:  430nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325736((R)-1-(3-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325734((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50:  720nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325725((R)-N-benzyl-1-(3-methoxyphenyl)ethanamine | CHEMB...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325726((R)-N-(2-chlorobenzyl)-1-(3-methoxyphenyl)ethanami...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325728((R)-N-(4-methoxybenzyl)-1-(3-methoxyphenyl)ethanam...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325729((R)-N-((2'-fluorobiphenyl-3-yl)methyl)-1-(3-methox...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325730((R)-1-(3-methoxyphenyl)-N-((2'-methylbiphenyl-3-yl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325731((R)-N-((2'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325732((R)-N-((4'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325733((R)-1-(3-methoxyphenyl)-N-((4'-(trifluoromethyl)bi...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325735((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325738((R)-N-((6-chloro-4'-(trifluoromethyl)biphenyl-3-yl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325725((R)-N-benzyl-1-(3-methoxyphenyl)ethanamine | CHEMB...)
Affinity DataEC50:  1.20E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed