Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50033387
TargetProstaglandin G/H synthase 1(Sheep)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ram seminal vesicle COX1 assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-laye...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50090808([1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 750nMAssay Description:Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 1(Sheep)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50344304(2-{1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of ovine COX1 assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 17 mins by thin-layer chromatograp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50344304(2-{1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of mouse COX2 assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 17 mins by thin-layer chromatograp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universit£T Leipzig

Curated by ChEMBL
LigandPNGBDBM50090808([1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of ram seminal vesicle COX1 assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-laye...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed