Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50040506
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50166908(CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...)
Affinity DataKi:  32.5nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395217(CHEMBL2164667 | US9150581, RTI-7527-168)
Affinity DataKi:  1.87E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395218(CHEMBL2164666 | US9150581, RTI-7527-192)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395219(CHEMBL2164665 | US9150581, RTI-7527-193)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395221(CHEMBL2164663 | US9150581, RTI-7527-153)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50171007(4-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-fluoro-pyri...)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50151495(2-[6-Fluoro-5-(4-nitro-phenyl)-pyridin-3-yl]-7-aza...)
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395221(CHEMBL2164663 | US9150581, RTI-7527-153)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395220(CHEMBL2164664 | US9150581, RTI-7527-(+/-)-154)
Affinity DataIC50: 1.90E+4nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50151495(2-[6-Fluoro-5-(4-nitro-phenyl)-pyridin-3-yl]-7-aza...)
Affinity DataIC50: 3.20E+4nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50395217(CHEMBL2164667 | US9150581, RTI-7527-168)
Affinity DataIC50: 3.50E+4nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50171007(4-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-2-fluoro-pyri...)
Affinity DataIC50: 9.80E+4nMAssay Description:Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 day...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed