Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50045674
TargetAdenosine kinase(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50094703(CHEMBL66089 | 5-(3-bromophenyl)-7-(6-morpholin-4-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of adenosine kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50135141(6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of recombinant Pneumocystis carinii DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELVAK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of ErbB-2 intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 17nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Orleans University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50: 19nMAssay Description:Inhibition of Pneumocystis carinii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50073942(CHEMBL3409483)
Affinity DataIC50: 21nMAssay Description:Inhibition of ErbB-2 intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50073942(CHEMBL3409483)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELVAK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50135141(6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d...)
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant human DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50073941(CHEMBL3409484)
Affinity DataIC50: 25nMAssay Description:Inhibition of EGFR intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELVAK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50073941(CHEMBL3409484)
Affinity DataIC50: 26nMAssay Description:Inhibition of ErbB-2 intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50073943(CHEMBL3409482)
Affinity DataIC50: 30nMAssay Description:Inhibition of ErbB-2 intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50073943(CHEMBL3409482)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR intracellular domain (unknown origin) purified from a baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELVAK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed