Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50006472
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM168435(US9675571, 129)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM340834(US9765018, Example 287)
Affinity DataIC50: 3nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM317549(US9624188, 30 | 3-(3-(3-(2,4- difluorophenyl)ureid...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500137(CHEMBL3747340)
Affinity DataIC50: 5nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of IFN-gamma-stimulated IDO1 activity in human HeLa cells using L-tryptophan as substrate after 48 hrs by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 72nMAssay Description:Inhibition of N-terminal His-tagged human recombinant IDO1 expressed in Escherichia coli using D-tryptophan as substrate by methylene blue/ascorbate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataKi:  94nMAssay Description:Inhibition of human recombinant IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM81348(R115 (Reactive Blue 2) | β-Lapachone (A3) | b...)
Affinity DataKi:  100nMAssay Description:Noncompetitive inhibition of human recombinant IDO1 expressed in Escherichia coli by Michaelis-Menton nonlinear regression plot analysis in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM387561(US10294212, No. 154 | N3-(3- Chloro-4- fluoropheny...)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal His-tagged human recombinant IDO1 expressed in Escherichia coli using tryptophan as substrate by UV-visible absorption spect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500142(CHEMBL3747530)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal hexa-Histidine tagged human IDO1 expressed in Escherichia coli using L-tryptophan as substrate after 30 mins by HPLC analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500136(CHEMBL3746040)
Affinity DataIC50: 240nMAssay Description:Inhibition of N-terminal His-tagged human recombinant IDO1 expressed in Escherichia coli using L-tryptophan as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500138(CHEMBL3745878)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IFN-gamma-stimulated IDO1 activity in human HeLa cells using L-tryptophan as substrate after 48 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50126144(CHEMBL3629569 | US10155972, Compound NewLink 1 | U...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500141(CHEMBL3746997)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM317215(US9617272, Compound 70 | US9981973, Compound 70)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal 6His-tagged human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50183456(N-methyl-N'-9-phenanthrylimidodicarbonimidic diami...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human recombinant IDO1 expressed in yeast IS20-2B using tryptophan as substrate by methylene blue/ascorbate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50030791(CHEMBL3342402)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human recombinant IDO1 expressed in Escherichia coli BL21 using tryptophan as substrate after 90 mins by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50279937(CHEMBL1985550)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of human recombinant IDO1 using L-tryptophan as substrate after 15 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500140(CHEMBL3103854)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of 6His-tagged human recombinant IDO1 expressed in Escherichia coli EC 539 using L-tryptophan as substrate after 1 hr by plate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500139(CHEMBL3745728)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant IDO1 expressed in Escherichia coli using L-tryptophan as substrate by methylene blue/ascorbate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50138821(CHEMBL3747548 | US9617272, Compound 66 | US9981973...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal 6His-tagged human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50146579(Benzyl-O-Hydroxylamine | O-Benzylhydroxylamine | C...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by spectrophoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM36371(CID2828334 | 5-(1H-indol-3-ylmethyl)-3-methyl-2-th...)
Affinity DataKi:  1.20E+4nMAssay Description:Competitive inhibition of 6His-tagged human recombinant IDO expressed in Escherichia coli BL21DE3pLysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500134(CHEMBL3747238)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of IDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50500135(CHEMBL3745836)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of IDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50024210(1H-indole-3-ethanamine | CHEMBL6640 | 2-(3-indolyl...)
Affinity DataKi:  1.60E+5nMAssay Description:Noncompetitive inhibition of human recombinant IDO1 expressed in Escherichia coli BL21 by Lineweaver-Burk double-reciprocal plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed