Compile Data Set for Download or QSAR
maximum 50k data
Found 35 Enz. Inhib. hit(s) with all data for entry = 50047639
TargetPotassium channel subfamily K member 2(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50180660((3S)-BUTYLPHTHALIDE)
Affinity DataIC50:  60nMAssay Description:Inhibition of of rat TREK1 expressed in CHO cells assessed as reversible current depressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180662(CHEMBL3817944)
Affinity DataIC50:  71nMAssay Description:Inhibition of of TREK1 (unknown origin) expressed in whole COS7 cells assessed as reduction in channel currents in presence of 10 uM arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium two pore domain channel subfamily K member 2(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50088383(Amlodipine | CHEBI:2668 | Norvasc)
Affinity DataIC50:  430nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium two pore domain channel subfamily K member 2(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50180663(CHEBI:7572 | CHEMBL1275655)
Affinity DataIC50:  750nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium two pore domain channel subfamily K member 2(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25759(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM79172(2-[4-[(3Z)-3-[2-(trifluoromethyl)-9-thioxanthenyli...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium two pore domain channel subfamily K member 2(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50017702(1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...)
Affinity DataIC50:  2.50E+3nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50066430(2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phe...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reversible current depressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50067133(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of of TASK1 (unknown origin) expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50067133(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of of human TREK1 expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 10(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25759(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of of TREK2 (unknown origin) expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium two pore domain channel subfamily K member 2(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)
Affinity DataIC50:  8.20E+3nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180661(Norfluoxetine)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of of human TREK1 expressed in tsA201 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of of human TREK1 expressed in tsA201 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM22871(13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azat...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25759(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
Affinity DataIC50:  2.03E+4nMAssay Description:Inhibition of of human TREK1 expressed in oocytes assessed as reversible current depressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 10(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25759(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of of TREK2 (unknown origin) expressed in oocytes assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  9.73E+4nMAssay Description:Inhibition of of TASK1 (unknown origin) expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  1.73E+5nMAssay Description:Inhibition of of human TREK1 expressed in CHO cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Affinity DataIC50:  2.07E+5nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180659(CHEMBL3818672)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of human TREK1 expressed in CHO cells assessed as increase in channel currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180658(CHEMBL3818800)
Affinity DataEC50:  2.13E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM30705(CHEMBL744 | MLS000069369 | RILUZOLE | SMR000058231...)
Affinity DataEC50:  1.39E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  3.60E+4nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  2.70E+4nMAssay Description:Activation of TRAAK (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  9.70E+3nMAssay Description:Activation of TREK1 (unknown origin) expressed in HEK293 cells assessed as increase in current density relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 10(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  3.00E+4nMAssay Description:Activation of TREK2 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataEC50:  1.00E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50180657(CHEMBL3819108)
Affinity DataEC50:  1.25E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed