Compile Data Set for Download or QSAR
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Found 69 Enz. Inhib. hit(s) with all data for entry = 50048067
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203332(CHEMBL3913908)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203339(CHEMBL3922888)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203337(CHEMBL3980889)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203335(CHEMBL3891718)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203333(CHEMBL3968178)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203341(CHEMBL3960724)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203342(CHEMBL3952032)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203334(CHEMBL3931836)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203336(CHEMBL3894912)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203335(CHEMBL3891718)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203338(CHEMBL3983734)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203335(CHEMBL3891718)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203331(CHEMBL3964421)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203337(CHEMBL3980889)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203333(CHEMBL3968178)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203339(CHEMBL3922888)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203333(CHEMBL3968178)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203340(CHEMBL3938615)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203336(CHEMBL3894912)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203340(CHEMBL3938615)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203336(CHEMBL3894912)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203339(CHEMBL3922888)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203332(CHEMBL3913908)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203337(CHEMBL3980889)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203340(CHEMBL3938615)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant CYP17 (unknown origin) overexpressed in human AD293 cells using [21-3H]17alpha-hydroxyl-pregenolone as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203342(CHEMBL3952032)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203342(CHEMBL3952032)
Affinity DataIC50:  78nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203341(CHEMBL3960724)
Affinity DataIC50:  82nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203341(CHEMBL3960724)
Affinity DataIC50:  87nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203333(CHEMBL3968178)
Affinity DataIC50:  99nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203331(CHEMBL3964421)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  116nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203334(CHEMBL3931836)
Affinity DataIC50:  123nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  133nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  136nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203335(CHEMBL3891718)
Affinity DataIC50:  145nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  146nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203341(CHEMBL3960724)
Affinity DataIC50:  148nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203337(CHEMBL3980889)
Affinity DataIC50:  151nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203342(CHEMBL3952032)
Affinity DataIC50:  153nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203338(CHEMBL3983734)
Affinity DataIC50:  158nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203332(CHEMBL3913908)
Affinity DataIC50:  162nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 21-hydroxylase(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203331(CHEMBL3964421)
Affinity DataIC50:  166nMAssay Description:Inhibition of recombinant CYP21 (unknown origin) overexpressed in human AD293 cells assessed as reduction in 11-deoxycortisol formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203331(CHEMBL3964421)
Affinity DataIC50:  185nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203339(CHEMBL3922888)
Affinity DataIC50:  185nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203334(CHEMBL3931836)
Affinity DataIC50:  187nMAssay Description:Inhibition of recombinant CYP11B1 (unknown origin) overexpressed in human AD293 cells assessed as reduction in cortisol formation preincubated for 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203336(CHEMBL3894912)
Affinity DataIC50:  198nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50203334(CHEMBL3931836)
Affinity DataIC50:  226nMAssay Description:Inhibition of human Cyp3A4 using testosterone as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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