Compile Data Set for Download or QSAR
maximum 50k data
Found 84 Enz. Inhib. hit(s) with all data for entry = 50048252
TargetEpidermal growth factor receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataKi:  0.140nMAssay Description:Inhibition of PF-06422899 binding to EGFR in human A431 cells after 1 hr by gel-based ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant MK2 (45 to 400 residues) (unknown origin) using fluorescein isothiocyanate-KKKALSRQLSVAA as substrateMore data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human NQO2 using menadione/CMCDP as substrate/cofactorMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Inhibition of recombinant human c-Met (974 to 1390 residues) using poly-Glu-Tyr as substrate preincubated for 20 mins followed by substrate and [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PF-06658607 binding to BTK in human Ramos cells after 1 hr by gel-based ABPP assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) in presence of dGTP and inorganic pyrophosphatase incubated for 15 mins ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human PLK1 (1 to 603 residues) expressed in baculovirus expression system using bovine milk casein as...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50402023(BI 6727 | VOLASERTIB)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human PLK1 (1 to 603 residues) expressed in baculovirus expression system using bovine milk casein as...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) in presence of dGTP and inorganic pyrophosphatase incubated for 15 mins ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM36409(2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataIC50:  8nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | CHEMBL541649 | D3RKN_6 | N-methyl-N...)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human recombinant PYK2 catalytic domain (416 to 692 residues) expressed in baculovi...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50:  12nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50156495(8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chro...)
Affinity DataIC50:  14nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  15nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50:  25nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  25nMAssay Description:Inhibition of N-terminal 6His-tagged human BRD4 bromodomain 1 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50:  28nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  28nMAssay Description:Inhibition of kinobead binding to ABL in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50:  32nMAssay Description:Inhibition of human full length CK1delta1 (2 to 415 residues) using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assayMore data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50:  32nMAssay Description:Inhibition of human full length polyhistidine-tagged CK1epsilon expressed in Escherichia coli BL21-Codon-Plus (DE3)-RIL using PLSRTLpSVASLPGL as subs...More data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50399656(CHEMBL2069623 | US11633415, Compound PF4800567)
Affinity DataIC50:  32nMAssay Description:Inhibition of human full length polyhistidine-tagged CK1epsilon expressed in Escherichia coli BL21-Codon-Plus (DE3)-RIL using PLSRTLpSVASLPGL as subs...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50399656(CHEMBL2069623 | US11633415, Compound PF4800567)
Affinity DataIC50:  32nMAssay Description:Inhibition of human full length CK1delta1 (2 to 415 residues) using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50210164(CHEMBL2132936)
Affinity DataIC50:  35nMAssay Description:Inhibition of N-terminal 6His-tagged human BRD4 bromodomain 1 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  43nMAssay Description:Inhibition of kinobead binding to NQO2 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  48nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  90nMAssay Description:Inhibition of kinobead binding to DDR1 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50210165(CHEMBL1709874)
Affinity DataIC50:  100nMAssay Description:Inhibition of DsRed-fused MTH1 (unknown origin) expressed in HEK293T cells using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50210163(CHEMBL3883604)
Affinity DataIC50:  100nMAssay Description:Inhibition of DsRed-fused MTH1 (unknown origin) expressed in HEK293T cells using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50: <100nMAssay Description:Inhibition of kinobead binding to DDR1 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50210164(CHEMBL2132936)
Affinity DataIC50:  110nMAssay Description:Inhibition of N-terminal 6His-tagged human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  130nMAssay Description:Inhibition of N-terminal 6His-tagged human BRD4 bromodomain 1 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM36371(5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidaz...)
Affinity DataIC50:  182nMAssay Description:Inhibition of recombinant human GST-fused RIPK1 (1 to 497 residues) expressed in baculovirus infected insect Sf9 cells in presence of 32P-gamma-ATP a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11279703, TABLE 6.171 | US11643396, E...)
Affinity DataIC50:  230nMAssay Description:Inhibition of N-terminal 6His-tagged human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  250nMAssay Description:Inhibition of kinobead binding to ABL in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
TargetBromodomain testis-specific protein(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal 6His-tagged human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  272nMAssay Description:Inhibition of kinobead binding to ARG in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  290nMAssay Description:Inhibition of N-terminal 6His-tagged human BRD4 bromodomain 1 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50352564(CHEMBL1825141)
Affinity DataIC50:  330nMAssay Description:Inhibition of His-tagged human MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate preincubated with protein followed by subs...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50411445(CHEMBL235658)
Affinity DataIC50:  330nMAssay Description:Inhibition of mouse N-terminal 5His-tagged p38alpha assessed as decrease in 6His-tagged MK2a (51 to 400 residues) phosphorylation in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  340nMAssay Description:Inhibition of N-terminal 6His-tagged human BRDT bromodomain 1 (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated histon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50352564(CHEMBL1825141)
Affinity DataIC50:  408nMAssay Description:Inhibition of His-tagged human MTH1 expressed in Escherichia coli BL21 (DE3) using 2-OH-dATP as substrate preincubated with protein followed by subst...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataIC50:  420nMAssay Description:Inhibition of immobilized N-LY294002 bead binding to PI3Kbeta (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 84 total ) | Next | Last >>
Jump to: