Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50019118
TargetSerine/threonine-protein kinase PLK1(Human)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615459(CHEMBL5281562)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length His-tagged human PLK1 expressed in baculovirus using biotinylated casein as substrate in presence of [gamma-33P]-ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615460(CHEMBL5271428)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human GST-tagged DYRK1A expressed in Escherichia coli using Woodtide as substrate in presence of [gamma-33P] ATP incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615458(CHEMBL5286820)
Affinity DataEC50:  44nMAssay Description:Agonist activity against PPAR-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHomeobox-leucine zipper protein PROTODERMAL FACTOR 2(Mouse-ear cress)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615456(CHEMBL5281600)
Affinity DataIC50: 890nMAssay Description:Inhibition of Arabidopsis thaliana expressed-sequence-tagged PDF2 using for-Met-Ala-Ser as substrate preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHomeobox-leucine zipper protein PROTODERMAL FACTOR 2(Mouse-ear cress)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50476209(CHEMBL374332)
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of Arabidopsis thaliana expressed-sequence-tagged PDF2 using for-Met-Ala-Ser as substrate preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetProstaglandin G/H synthase 2(Human)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50075510(5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human COX-2 using [14C]arachidonic acid as substrate incubated for 1 mins by radiometric HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615461(CHEMBL376044)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615462(CHEMBL5280080)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetBeta-3 adrenergic receptor(Human)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50099161(N-[5-(2-{1-[4-(2,4-Dioxo-thiazolidin-5-ylidenemeth...)
Affinity DataEC50:  6.00E+3nMAssay Description:Agonist activity against human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetLethal factor(Bacillus anthracis)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM8436(2-[(5Z)-5-(furan-2-ylmethylidene)-4-oxo-2-sulfanyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Bacillus anthracis anthrax lethal factor using MAPKKide as substrate incubated for 30 mins by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetLethal factor(Bacillus anthracis)
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615457(CHEMBL211933)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Bacillus anthracis anthrax lethal factor using MAPKKide as substrate incubated for 30 mins by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615465(CHEMBL5272023)
Affinity DataIC50: 1.98E+7nMAssay Description:Inhibition of Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50334180(2-(4-oxo-5-(3-phenoxybenzylidene)-2-thioxothiazoli...)
Affinity DataIC50: 1.98E+7nMAssay Description:Inhibition of Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615463(CHEMBL5279984)
Affinity DataIC50: 1.98E+7nMAssay Description:Inhibition of Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Danylo Halytsky Lviv National Medical University

Curated by ChEMBL
LigandPNGBDBM50615464(CHEMBL240020)
Affinity DataIC50: 1.98E+7nMAssay Description:Inhibition of Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed