Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50002724
TargetProthrombin(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50147818((2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-...)
Affinity DataKi:  0.00100nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
TargetPlasma kallikrein(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50462133(CHEMBL4238882)
Affinity DataKi:  0.0200nMAssay Description:Competitive inhibition of human plasma kallikrein using S2302 as substrate by UV-visible spectrophotometerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human factor 10a using pefachrome F10a as substrate preincubated for 10 mins followed by substrate addition and measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50458534(CHEMBL4216226)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human factor 11a using pyroGlu-Pro-Arg-pNA.HCl as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProthrombin(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50150293((S)-1-((R)-2-Hydroxy-3,3-dimethyl-butyryl)-pyrroli...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human thrombin using spectrozyme PL as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50462133(CHEMBL4238882)
Affinity DataKi:  2.20nMAssay Description:Competitive inhibition of human plasmin using chromozyme PL as substrate by UV-visible spectrophotometerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50147828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  3nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor IX(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50462134(CHEMBL4247345)
Affinity DataKi:  3.5nMAssay Description:Inhibition of recombinant human factor 9aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50112086(3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM12753(N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-1-(...)
Affinity DataKi:  13nMAssay Description:Inhibition of recombinant human factor 9a using MS-D-HHT-Gly-Arg-pNA as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50462133(CHEMBL4238882)
Affinity DataKi:  18nMAssay Description:Competitive inhibition of human factor 11a using pefachrome PCa as substrate by UV-visible spectrophotometerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50462132(CHEMBL502016)
Affinity DataKi:  20nMAssay Description:Inhibition of bovine alpha thrombin using H-D-Phe-PigArg-pNA as substrate by spectrophotometerMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50070629(4-[2-(3-Benzenesulfonylamino-5-methyl-phenoxy)-eth...)
Affinity DataKi:  23nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50462133(CHEMBL4238882)
Affinity DataKi:  45nMAssay Description:Competitive inhibition of human factor 10a using pefachrome F10a as substrate by UV-visible spectrophotometerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50112086(3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)
Affinity DataKi:  50nMAssay Description:Inhibition of human trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50462135(CHEMBL1230094)
Affinity DataIC50:  93nMAssay Description:Inhibition of human TF/F7a using spectrozyme f7a as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB