Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50002890
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0100nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50026603(CHEBI:3216 | Buprenorphine)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin) assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50026614(CHEMBL575508)
Affinity DataKi:  0.0530nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50464462(CHEMBL4283681)
Affinity DataKi:  0.170nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50012152(CHEMBL3264441)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50464462(CHEMBL4283681)
Affinity DataKi:  3.30nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50464462(CHEMBL4283681)
Affinity DataKi:  5.30nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50464461(CHEMBL4290635)
Affinity DataKi:  10nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50027038(CHEMBL2112474)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50464460(CHEMBL4295159)
Affinity DataKi:  30nMAssay Description:Antagonist activity at kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50026614(CHEMBL575508)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 47nMAssay Description:Displacement of [3H]CI-977 from kappa opioid receptor in guinea pig brain membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50012151(CHEMBL3264440)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]-diprenorphine from rat mu-opioid receptor in expressed in rat C6 cell membranes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50012150(CHEMBL3264439)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]-diprenorphine from rat mu-opioid receptor in expressed in rat C6 cell membranes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50012150(CHEMBL3264439)
Affinity DataKi:  135nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50027038(CHEMBL2112474)
Affinity DataKi:  164nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50027051(CHEMBL2112472)
Affinity DataKi:  164nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50012151(CHEMBL3264440)
Affinity DataKi:  174nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 260nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in guinea pig brain membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130563((R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl...)
Affinity DataKi: >300nMAssay Description:Displacement of [3H]DADLE from delta-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50026614(CHEMBL575508)
Affinity DataKi:  616nMAssay Description:Displacement of [3H]DADLE from delta-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50027051(CHEMBL2112472)
Affinity DataKi:  764nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetOpioid receptor delta 1(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [3H]DPDPE from delta-opioid receptor in guinea pig brain membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50027038(CHEMBL2112474)
Affinity DataKi: >3.40E+3nMAssay Description:Displacement of [3H]DADLE from delta-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50027051(CHEMBL2112472)
Affinity DataKi: >4.90E+3nMAssay Description:Displacement of [3H]DADLE from delta-opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed