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Found 12 Enz. Inhib. hit(s) with all data for entry = 50009537
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50529710(CHEMBL4449273)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50529710(CHEMBL4449273)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50529711(CHEMBL514508)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50529711(CHEMBL514508)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50101971(BAY-E-9736 | CHEBI:7575 | Nimodipine | Nimotop)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50101971(BAY-E-9736 | CHEBI:7575 | Nimodipine | Nimotop)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50293136(4-Chloro-17-Azapentacycle[6.6.5.0(2,7).0(9,14).0(1...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50529709(CHEMBL4590632)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50293136(4-Chloro-17-Azapentacycle[6.6.5.0(2,7).0(9,14).0(1...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1F(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50529709(CHEMBL4590632)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed