Compile Data Set for Download or QSAR
maximum 50k data
Found 13 Enz. Inhib. hit(s) with all data for entry = 50008380
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518648(CHEMBL4438364)
Affinity DataIC50:  550nMAssay Description:Inhibition of deacetylation activity of recombinant human N-terminal His6-tagged SIRT2 (2 to 389 residues) expressed in Escherichia coli using H2N-HK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518647(CHEMBL4440955)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of deacetylation activity of recombinant human N-terminal His6-tagged SIRT3 (101 to 399 residues) expressed in Escherichia coli using H2N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518647(CHEMBL4440955)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant human SIRT1 deacetylase activity using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate measured after 10 mins by HPLC ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518648(CHEMBL4438364)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of deacetylation activity of recombinant human N-terminal His6-tagged SIRT3 (101 to 399 residues) expressed in Escherichia coli using H2N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518648(CHEMBL4438364)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of recombinant human SIRT1 deacetylase activity using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate measured after 10 mins by HPLC ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518648(CHEMBL4438364)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of tRNA-activated deacetylation activity of recombinant human full length N-terminal His6-tagged SIRT7 expressed in Escherichia coli using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-6(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518647(CHEMBL4440955)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of demyristoylation activity of recombinant human full length N-terminal His6-tagged SIRT6 expressed in Escherichia coli using H2N-EALPK-[...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518647(CHEMBL4440955)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of deacetylation activity of recombinant human N-terminal His6-tagged SIRT2 (2 to 389 residues) expressed in Escherichia coli using H2N-HK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518647(CHEMBL4440955)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of tRNA-activated deacetylation activity of recombinant human full length N-terminal His6-tagged SIRT7 expressed in Escherichia coli using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-6(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518648(CHEMBL4438364)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of demyristoylation activity of recombinant human full length N-terminal His6-tagged SIRT6 expressed in Escherichia coli using H2N-EALPK-[...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518646(CHEMBL4522166)
Affinity DataIC50:  8.53E+4nMAssay Description:Inhibition of tRNA-activated deacetylation activity of recombinant human full length N-terminal His6-tagged SIRT7 expressed in Escherichia coli using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518647(CHEMBL4440955)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of desuccinylation activity of recombinant human full length N-terminal GST-tagged SIRT5 expressed in Escherichia coli using CH3CONH-AR-[N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50518648(CHEMBL4438364)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of desuccinylation activity of recombinant human full length N-terminal GST-tagged SIRT5 expressed in Escherichia coli using CH3CONH-AR-[N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed